Application of non-invasive preimplantation genetic screening for aneuploidy through spent embryo culture media analysis at 48 and 54 hours after embryo cleavage - Takeaways - MDSpire

Application of non-invasive preimplantation genetic screening for aneuploidy through spent embryo culture media analysis at 48 and 54 hours after embryo cleavage

  • By

  • Chonthicha Satirapod

  • Pornsri Niransuk

  • Siriluk Tantanavipas

  • Insee Sensorn

  • Wasun Chantratita

  • Objoon Trachoo

  • June 9, 2026

  • 0 min

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  • 1

    The study evaluated non-invasive preimplantation genetic testing (niPGT) for aneuploidy detection at 48 and 54 hours post-cleavage.

  • 2

    Fifteen infertile women participated, resulting in a total of 58 embryos analyzed through spent culture media (SCM) collection.

  • 3

    The accuracy of niPGT for ploidy detection was found to be 53.71%, with no significant difference between the two time points.

  • 4

    The overall accuracy for sex determination using niPGT reached 79.63% across the analyzed embryos.

  • 5

    The concentration of cell-free DNA in SCM was consistent at both 48 and 54 hours after embryo cleavage.

Original Source(s)

Application of non-invasive preimplantation genetic screening for aneuploidy through spent embryo culture media analysis at 48 and 54 hours after embryo cleavage

  • by Chonthicha Satirapod, Pornsri Niransuk, Siriluk Tantanavipas, Insee Sensorn, Wasun Chantratita, Objoon Trachoo

  • June 9, 2026

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