Brucella proline racemase protein A targets Tpl2 to promote IL-10 secretion for establishment of chronic infection - Takeaways - MDSpire

Brucella proline racemase protein A targets Tpl2 to promote IL-10 secretion for establishment of chronic infection

  • By

  • Huan Zhang

  • Xueyu Tao

  • Yuanzhi Wang

  • Yueli Wang

  • Huilin Hou

  • Xiaoyu Deng

  • Zhenyu Xu

  • Xujin Xia

  • Mingguo Xu

  • Zhen Wang

  • Changsuo Zhang

  • Zhumanov Kairat Toksanbaevich

  • Jinliang Sheng

  • Zhongchen Ma

  • Jihai Yi

  • Chuangfu Chen

  • June 9, 2026

  • 0 min

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  • 1

    Brucella melitensis PrpA activates the Tpl2-ERK signaling pathway in macrophages, enhancing IL-10 production and facilitating chronic infection.

  • 2

    Tpl2 deletion impairs macrophage bactericidal ability and reduces levels of TNF-α, IL-1β, and IL-10, indicating its role in immune response.

  • 3

    PrpA deletion in Brucella melitensis increases IFN-γ levels and T cell responses, suggesting its importance in immune evasion.

  • 4

    The B. melitensis M5–90 prpA mutant offers greater protection against virulent Brucella melitensis M28 infection in mice compared to the parental strain.

  • 5

    These findings highlight PrpA as a critical virulence factor that modulates immune responses, presenting the prpA mutant as a potential vaccine candidate.

Original Source(s)

Brucella proline racemase protein A targets Tpl2 to promote IL-10 secretion for establishment of chronic infection

  • by Huan Zhang, Xueyu Tao, Yuanzhi Wang, Yueli Wang, Huilin Hou, Xiaoyu Deng, Zhenyu Xu, Xujin Xia, Mingguo Xu, Zhen Wang, Changsuo Zhang, Zhumanov Kairat Toksanbaevich, Jinliang Sheng, Zhongchen Ma, Jihai Yi, Chuangfu Chen

  • June 9, 2026

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