Chronic military stress and glandular epithelial tumor biology: an integrative neuroendocrine–inflammatory framework with insights from microgravity gene discovery

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Prolonged military stress can lead to PTSD, which is linked to dysregulation of neuroendocrine and inflammatory pathways.
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Chronic stress is associated with increased incidence of glandular epithelial tumors, including hepatocellular carcinoma and prostatic adenocarcinoma.
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Key molecules such as NR3C1, FKBP5, and IL-6 play critical roles in the relationship between chronic stress and tumor biology.
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The glucocorticoid receptor and FKBP5 influence metabolic and proliferative networks, affecting cancer progression under chronic stress.
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Understanding the interplay between stress and tumor dynamics is essential for developing targeted therapies in high-risk populations.

Frontiers In Oncology

by David Laván, Natalia Argüelles, Rosa Rea, José Morales, Sofia Montes, Daniel Huaman, Alexis Lluncor, Juan Moyano, Milton Peña, Vilma Herencia-Reyes, Alcides Guerra, Gabriela Calderón, José M. Vela-Ruiz, Aly Gallo
June 9, 2026

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