Follicular development during the follicular phase of the menstrual cycle: the enigma of luteinizing hormone receptor function - Takeaways - MDSpire

Follicular development during the follicular phase of the menstrual cycle: the enigma of luteinizing hormone receptor function

  • By

  • Claus Yding Andersen

  • Liv la Cour Poulsen

  • Marie Louise Wissing

  • Malene Louise Johannsen

  • June 9, 2026

  • 0 min

Share

  • 1

    The luteinizing hormone receptor (LHR) is crucial for follicular development and steroidogenesis in the menstrual cycle.

  • 2

    The Rainbow RCT found that increasing doses of recombinant hCG negatively impacted blastocyst quality and pregnancy rates.

  • 3

    Divergent hormonal responses in the Rainbow trial suggest differences in LHR expression and function between granulosa and theca cells.

  • 4

    Constant exposure to rhCG may alter LHR dynamics, leading to reduced granulosa cell function while maintaining theca cell activity.

  • 5

    The study highlights the need for further investigation into LHR regulation to optimize ovarian stimulation protocols in IVF.

Original Source(s)

Follicular development during the follicular phase of the menstrual cycle: the enigma of luteinizing hormone receptor function

  • by Claus Yding Andersen, Liv la Cour Poulsen, Marie Louise Wissing, Malene Louise Johannsen

  • June 9, 2026

Related Content

Endometriotic cyst mimicking recurrence after treatment for ovarian immature teratoma: a case report

HHS Seeks Broader Access to Health Data

"We can’t do anything our agreements don’t allow us to do"

IGF-II, IGFBP-4, -6, and -7, and HMGB1 show changes in follicular fluid in PCOS