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MDSpire News

  • October 28, 2026
FDA adds generic valganciclovir oral solution
  • Mouj Hijazi
  • October 28, 2026
  • 2 min

Objective: The article examines the objective, findings, and clinical context described in FDA adds generic valganciclovir oral solution. Approach: Approval: FD

...more
2 min

MDSpire News

  • October 28, 2026
PET/MRI may reveal MRI-occult inflammation
  • Andrea Surnit
  • October 28, 2026
  • 4 min

Objective: To describe the use of F-18–DPA714 PET/MRI to assess neuroinflammation in a patient with anti-vimentin IgG-associated autoimmune encephalitis and unr

...more
2 min

MDSpire News

  • October 28, 2026
Miliary tuberculosis may masquerade as toxoplasmosis
  • Andrea Surnit
  • October 28, 2026
  • 4 min
  1. A 30-year-old woman had multiple rim-enhancing brain lesions on routine MRI despite no initial fever, pulmonary symptoms, or neurologic abnormalities.
  2. The MRI findings suggested toxoplasmosis or neurocysticercosis, but chest CT showed bilateral 1- to 3-mm pulmonary nodules consistent with miliary tuberculosis.
  3. Sputum PCR detected Mycobacterium tuberculosis complex DNA, whereas sputum cultures and CSF tuberculosis PCR were negative and CSF analysis was unremarkable.
  4. The researchers diagnosed probable parenchymal CNS tuberculosis with miliary pulmonary tuberculosis and treated the patient with antituberculosis drugs and adjunctive corticosteroids.
  5. After 12 months of therapy, brain lesions regressed, and complete clinical and radiologic remission was documented 12 months after treatment.
...more

MDSpire News

  • October 28, 2026
Persistent anxiety linked to cognitive lapses
  • Andrea Surnit
  • October 28, 2026
  • 4 min

Objective: To examine associations between anxiety, depressive symptoms, physical activity, and self-reported cognitive difficulties during pregnancy and early

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The Pathologist

  • October 28, 2026
I Was 36 Years Old and Head of Pathology
  • Helen Bristow
  • October 28, 2026
  • 8 min
  1. Aleš Ryška became chair of the pathology department at age 36 after his predecessor reached the mandatory retirement age and Ryška was the only potential internal candidate.
  2. Ryška had no formal leadership training; he drew on Boy Scout experience and advice from his predecessor, who remained in the department after stepping down.
  3. To preserve his diagnostic and clinical work amid increased administrative duties, Ryška reduced his research activities, a decision he still regrets.
  4. Ryška adopted a democratic approach, discussing proposed changes with the team and avoiding major reforms because the department was functioning well.
  5. He reorganized pathology coverage by creating small specialist groups for lower-volume areas and distributing high-demand work across staff, making the department more flexible.
...more

MDSpire News

  • October 28, 2026
NUT carcinoma may defy typical staining patterns
  • Andrea Surnit
  • October 28, 2026
  • 4 min

Objective: To describe variation in morphology, immunohistochemical findings, and clinical course in two patients with pulmonary NUT carcinoma. Approach: Cases:

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2 min

MDSpire News

  • October 28, 2026
Anti-CGRP antibodies may raise miscarriage risk
  • Andrea Surnit
  • October 28, 2026
  • 4 min

Objective: To assess whether exposure to anti-CGRP monoclonal antibodies or propranolol was associated with spontaneous abortion among pregnancies in patients w

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2 min

MDSpire News

  • October 28, 2026
Magical practice may not signal belief
  • Andrea Surnit
  • October 28, 2026
  • 5 min
  1. A conceptual synthesis in Evolution and Human Behavior examined whether magical practices reflect genuine belief or other attitudes, including imagination, symbolism, and make-believe.
  2. The researchers argued that neither genuine belief nor non-doxastic commitment should be treated as the default explanation for magical practice.
  3. Seeking magical help for consequential problems, choosing shamans with better track records, and changing methods after failures were cited as evidence of genuine belief.
  4. Ethnographic examples showed that some people participate in magical rituals despite skepticism, potentially because of social obligations or a desire to hedge against possible efficacy.
  5. The authors proposed a heterogeneous account of attitudes but said available evidence cannot establish how common each attitude is or reliably classify individual practitioners.
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The Pathologist

  • October 28, 2026
AI Diagnostic Tool Outperforms Clinicians
  • October 28, 2026
  • 2 min

Objective: To evaluate whether Diagnostic Orchestrator (DxO), an AI system that selects tests and updates diagnoses as evidence emerges, can improve diagnostic

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2 min

The Medicine Maker

  • October 28, 2026
Video: Leading the Alpha Charge – with Øystein Soug
  • October 28, 2026
  • 1 min
  1. Øystein Soug leads Oncoinvent after a career spanning military training, finance roles in Russia and China, and more than a decade as a CFO.
  2. Oncoinvent is developing Radspherin, a receptor-independent alpha-emitting radiopharmaceutical for cancers that have spread to the abdominal cavity.
  3. Radspherin is delivered directly into the peritoneum to concentrate radiation around residual cancer cells while limiting exposure elsewhere in the body.
  4. Soug discusses lessons from helping bring Xofigo to market and identifies manufacturing and supply chains as persistent radiopharmaceutical challenges.
  5. Soug also discusses new isotopes, delivery methods, combination strategies, Oslo’s radiopharmaceutical sector, and the practical demands of leadership.
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The Medicine Maker

  • October 28, 2026
Prime Editing Creates Drug-Controllable T Cell Therapies
  • October 28, 2026
  • 3 min
  1. A preclinical prime-editing platform engineered therapeutic T cells to resist tacrolimus while remaining sensitive to cyclosporin.
  2. In T cells from 3 patients with HAVCR2-associated lymphoma, prime editing corrected the pathogenic variant in 18.7% to 35.8% of cells and restored TIM-3 expression in up to 44.4%.
  3. In humanized mice, tacrolimus selection increased corrected HAVCR2 sequences to an average of 76.8% of spleen reads after 8 weeks, compared with 9.3% without selection.
  4. Tacrolimus-exposed, edited CD19-directed CAR T cells retained viability, proliferation, and tumor-killing activity, and maintained tumor control in mice with CD19-positive tumors.
  5. The researchers also tested edits for resistance to methotrexate and mycophenolate, with resistance varying by edit.
...more

The Medicine Maker

  • October 28, 2026
Engineering a New Generation of Cancer-Fighting Cells
  • October 28, 2026
  • 3 min

Objective: To develop a scalable platform for expanding and genetically engineering granulocyte-monocyte progenitors (GMPs) for potential CAR-based cancer immun

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2 min

The Analytical Scientist

  • October 28, 2026
GC×GC Detective Stories: Closing the Case?
  • Pierre-Hugues Stefanuto
  • October 28, 2026
  • 8 min

Objective: Review the development, applications, strengths, and remaining challenges of comprehensive two-dimensional gas chromatography (GC×GC), as presented i

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3 min

The Analytical Scientist

  • October 28, 2026
Two Combs, One Detailed Molecular Picture
  • October 28, 2026
  • 3 min

Objective: Review developments in dual-comb spectroscopy in the mid-infrared and terahertz regions and compare technologies used to generate frequency combs. Ap

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2 min

The Analytical Scientist

  • October 28, 2026
Raman Spectroscopy Distinguishes SARS-CoV-2 Variants
  • October 28, 2026
  • 3 min

Objective: To assess whether Raman spectroscopy with spectral barcoding can distinguish RNA from SARS-CoV-2 variants and subvariants. Approach: Samples: Researc

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2 min

Jama Network Open

  • October 28, 2026
Corrections to the Results, Figure, and Table
  • October 28, 2026

Objective: Report corrections made to the Original Investigation “Lancet Definition vs Other Criteria for Obesity Diagnosis in Adults.” Approach: Results: Place

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1 min

Jama Network Open

  • October 28, 2026
Metabolic Changes in Youth Treated With Antipsychotics Over Varying Exposure Durations
  • Song Song
  • Wenxin Tian
  • Yuqi Hu
  • Cuiling Wei
  • Xinya Mu
  • Rachel Yui Ki Chu
  • Yifang Huang
  • Zijie Xu
  • Heidi Ka Ying Lo
  • Amy Pui Pui Ng
  • Queenie Wing Shan See
  • William Chi Wai Wong
  • Esther Wai Yin Chan
  • Ian Chi Kei Wong
  • Francisco Tsz Tsun Lai
  • October 28, 2026
  1. This first-event self-controlled case series used Hong Kong public health records to assess metabolic abnormalities after antipsychotic initiation in patients aged 6 to 17 years.
  2. Among 15,219 antipsychotic initiators, 497 developed metabolic abnormalities: 115 had hyperglycemia and 447 had dyslipidemia.
  3. Compared with baseline periods, metabolic abnormality incidence was elevated on days 8 to 30 after initiation (IRR, 5.60; 95% CI, 2.93-10.70) and peaked on days 31 to 90 (IRR, 7.71; 95% CI, 5.15-11.55
  4. Incidence remained elevated after 90 days of initial exposure (IRR, 3.94; 95% CI, 2.91-5.33) and during subsequent exposure episodes (IRR, 3.71; 95% CI, 2.51-5.49).
  5. The authors cautioned that increased testing near treatment initiation, delayed detection of preexisting abnormalities, and residual time-varying confounding may have influenced the observed patterns.
...more

Clinical Rheumatology

  • October 28, 2026
Sleeve and Holster Skin Signs Associated With Dermatomyositis
  • Kazuhiko Hirokawa
  • Yoshitaka Ueda
  • Naoto Yokogawa
  • October 28, 2026

Objective: The article examines the objective, findings, and clinical context described in Sleeve and Holster Skin Signs Associated With Dermatomyositis. Approa

...more
2 min