Comparison between germline and somatic loss-of-function RNF43 mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis

• By

• Claire Palles

• Luke Freeman-Mills

• Edward Arbe-Barnes

• Nathalie Feeley

• Laura Chegwidden

• Helen Curley

• Sara Galavotti

• Connor Woolley

• Jeremy Cheadle

• Dmitri Mouradov

• Oliver Sieber

• Silvia Salatino

• Steve Thorn

• Anshita Goel

• Juan Fernandez-Tajes

• Sulochana Omwenga

• Sujata Biswas

• Timothy Maughan

• Simon J Leedham

• S:CORT Consortium

• UK Colorectal Cancer Genomics Consortium

• CORGI Consortium

• WGS500 Consortium

• Viktor Hendrik Koelzer

• Lai Mun Wang

• Roland Arnold

• James Edward East

• Ian Tomlinson

• July 1, 2026

• 0 min

• Gut