DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) mutations limit normal and autoreactive CD4+ T follicular helper responses and attenuate T cell-driven joint inflammation - Poll - MDSpire

Mutations in DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) impair both typical and autoreactive CD4+ T follicular helper cell functions and reduce T cell-mediated joint inflammation

  • By

  • Yunbing Shen

  • Sanjaykumar Boddul

  • Zhaojun Li

  • Zsolt Kasza

  • Marlene Schülein

  • Bruno Raposo

  • Karine Chemin

  • Per-Johan Jakobsson

  • Alexander Espinosa

  • Lars Klareskog

  • Fredrik Wermeling

  • June 29, 2026

Share

Original Source(s)

DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) mutations limit normal and autoreactive CD4+ T follicular helper responses and attenuate T cell-driven joint inflammation

  • by Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per-Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling

  • June 29, 2026

Related Content

Predicting anti-CCP positivity and early rheumatoid arthritis onset from routine laboratory parameters: a SHAP-explained machine learning pipeline

Autoantibodies to Joint-Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

Hair Repigmentation Reported With Baricitinib in Canities Subita

A single case suggests a possible benefit, but confounding factors and the off-label setting temper the conclusions.