Single-cell eQTL Mendelian randomization reveals the monocyte-associated PRKCB–CTSL axis as a candidate regulatory pathway and potential therapeutic target in rheumatoid arthritis

• by Pengli Wang, Guohang Shen, Wenhua Liao, Ruoyan Wang, Li Zhang, Mingjia Zhao, Dong Zhang, Nanxiang Huang, Yupei Dai

• October 19, 2026

RA Outcomes Improved in KURAMA Cohort

Ten-year observational data showed lower disease activity and functional disability coinciding with broader use of biologic and targeted synthetic therapies.

• by Andrea Surnit

• May 22, 2026

• 4 min

Autoantibodies to Joint-Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

• by Outi Sareila, Linda Johansson, Anders Lundquist, Monica Leu Agelii, Lei Cheng, Yibo He, Erik Lönnblom, Maria Andersson, Jan Kihlberg, Anders Esberg, Inger Gjertsson, Rikard Holmdahl, Solbritt Rantapää-Dahlqvist

• May 27, 2026

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

• by Rachael A. Gordon, Sara S. McCoy

• July 1, 2026