Fulminant cerebral edema in the setting of acute dengue fever after mechanical thrombectomy in a patient with massive stroke and severe hypoalbuminemia: a case report - Report - MDSpire

Fulminant cerebral edema in the setting of acute dengue fever after mechanical thrombectomy in a patient with massive stroke and severe hypoalbuminemia: a case report

  • By

  • Haiwen Huang

  • Ying Li

  • Yonglin Li

  • Zhihua Liu

  • Jiajing Hu

  • May 14, 2026

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Severe Cerebral Edema Following Mechanical Thrombectomy in a Patient with Acute Dengue Fever

Overview

Revise to better explain the relationship between hypoalbuminemia and cerebral edema in dengue patients.

Background

Malignant cerebral edema is a serious complication following mechanical thrombectomy, significantly increasing mortality rates in patients with large vessel occlusion strokes. Understanding the contributing factors, including systemic inflammation and pre-existing conditions such as hypoalbuminemia, is essential for improving patient outcomes. This case underscores the need for heightened vigilance in post-thrombectomy care, particularly in patients with concurrent systemic infections.

Data Highlights

Incorporate qualitative findings from the case to provide a more comprehensive overview.

Key Findings

  • A 61-year-old male with a history of nephrotic syndrome presented with a left middle cerebral artery infarction.
  • Mechanical thrombectomy was performed 20 hours after symptom onset, followed by rapid neurological decline.
  • Acute dengue fever was diagnosed post-procedure, coinciding with a systemic inflammatory response.
  • Cerebral edema escalated rapidly, with midline shift increasing from 4 mm to 11 mm within 20 hours.
  • Severe hypoalbuminemia (14.8 g/L) may have contributed to the patient's susceptibility to cerebral edema.
  • The case illustrates the complex interaction between systemic inflammatory stressors and post-reperfusion cerebral edema.

Clinical Implications

Highlight the need for monitoring inflammatory markers in post-thrombectomy care.

Conclusion

This case study emphasizes the importance of considering systemic factors, such as infections and hypoalbuminemia, in the management of patients undergoing mechanical thrombectomy for stroke, as they may significantly influence clinical outcomes.

Related Resources & Content

  1. Frontiers in Neurology, 2026 -- Association of uric acid levels with the risk of severe CED in LVO-AIS patients after mechanical thrombectomy
  2. Intensive Care Medicine, 2016 -- Guidelines for Managing Severe Malaria and Severe Dengue in Low-Resource Environments
  3. Endoscopic Third Ventriculostomy in a Patient with Hydrocephalus Associated with Dural Arteriovenous Fistula: A Case Study and Review of Existing Literature
  4. 2026 Guideline for the Early Management of Patients With AIS - Professional Heart Daily | American Heart Association
  5. Impact of Early Cerebrospinal Fluid Drainage on the Severity of Initial Brain Injury Following Aneurysmal Subarachnoid Hemorrhage
  6. WHO Guidelines for clinical management of arboviral diseases: dengue, chikungunya, Zika, and yellow fever
  7. 2026 Guideline for the Early Management of Patients With AIS - Professional Heart Daily | American Heart Association
  8. Neuroimaging predictors of malignant brain oedema after thrombectomy in ischemic stroke: a systematic review and meta-analysis - PubMed

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