Case Report: Contrast-enhanced ultrasonography for evaluating a newly detected contralateral pulmonary lesion during non-small cell lung cancer chemoimmunotherapy - Report - MDSpire

Case Report: Contrast-enhanced ultrasonography for evaluating a newly detected contralateral pulmonary lesion during non-small cell lung cancer chemoimmunotherapy

  • By

  • Yang Liu

  • Lusi Feng

  • Xiaoqian Yang

  • Shiyu Wen

  • Yu Xiang

  • Xuelei Ma

  • Rongxing Zhou

  • Wei Du

  • May 21, 2026

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Clinical Report: Utilizing Contrast-Enhanced Ultrasonography in NSCLC

Overview

This report discusses the use of contrast-enhanced ultrasonography (CEUS) to evaluate a newly identified contralateral pulmonary lesion in a patient undergoing chemoimmunotherapy for non-small cell lung cancer (NSCLC). CEUS provided valuable information that suggested an inflammatory process rather than malignancy, which was later confirmed by clinical follow-up.

Background

The emergence of new pulmonary lesions during chemoimmunotherapy for NSCLC presents a diagnostic challenge, as these lesions may indicate tumor progression, infection, or benign processes. Traditional imaging methods like computed tomography (CT) may not always provide sufficient clarity for diagnosis. CEUS offers real-time perfusion assessment, potentially enhancing the diagnostic accuracy for peripheral pulmonary lesions.

Data Highlights

No numerical data or trial data was provided in the source material.

Key Findings

  • CEUS demonstrated rapid hyperenhancement in the pulmonary arterial phase of the lesion.
  • The lesion exhibited relatively homogeneous internal enhancement and slight persistent hyperenhancement in the venous phase.
  • Clinical follow-up showed marked regression of the lesion after anti-infective treatment.
  • CEUS is most effective when used in conjunction with clinical, laboratory, and imaging data.
  • New pulmonary lesions during therapy require careful evaluation to differentiate between malignancy and other processes.

Clinical Implications

Healthcare professionals should consider integrating CEUS into the diagnostic workflow for patients with newly detected pulmonary lesions during chemoimmunotherapy. This approach may improve the differentiation between inflammatory and malignant processes, potentially avoiding unnecessary interventions.

Conclusion

The case illustrates the adjunctive role of CEUS in evaluating pulmonary lesions in NSCLC patients undergoing treatment. Its integration with other clinical data enhances diagnostic confidence and patient management.

Related Resources & Content

  1. NCCN Clinical Practice Guidelines in Oncology, 2024 -- Non-Small Cell Lung Cancer
  2. WFUMB Technological Review -- How to Perform Contrast-Enhanced Ultrasound of the Lung
  3. Frontiers in Oncology — Latent class analysis of conventional ultrasound features: a novel approach to predicting non-response to neoadjuvant chemotherapy in breast cancer
  4. roswell park comprehensive cancer center — Lung Suffusion Clinical Trial
  5. The ASCO Post — Intensity-Modulated vs Three-Dimensional Conformal External-Beam Radiation Therapy in Locally Advanced Non–Small Cell Lung Cancer
  6. The ASCO Post — Primary Lung Tumor SBRT Followed by Concurrent Mediastinal Chemoradiotherapy and Immunotherapy Consolidation in Locally Advanced NSCLC
  7. Lung Suffusion Clinical Trial
  8. Intensity-Modulated vs Three-Dimensional Conformal External-Beam Radiation Therapy in Locally Advanced Non–Small Cell Lung Cancer
  9. Non-Small Cell Lung Cancer, Version 4.2024, NCCN Clinical Practice Guidelines in Oncology - PubMed
  10. WFUMB Technological Review: How to Perform Contrast-Enhanced Ultrasound of the Lung - PubMed

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