Correlation between cardiorespiratory fitness and body composition in individuals with different glucose metabolism statuses

By
Binbin Liu
Junliang Li
Ziru Niu
Qiang Lu
May 29, 2026

Frontiers In Endocrinology

Overview

This study investigates the correlation between cardiorespiratory fitness (CRF) and body composition across different glucose metabolism statuses. Significant differences in fitness and body composition metrics were found among groups categorized by glucose tolerance, highlighting the importance of these factors in assessing health risks.

Background

Diabetes mellitus is a prevalent chronic condition that significantly impacts cardiovascular health and overall mortality. Understanding the relationship between CRF and body composition in individuals with varying glucose metabolism can inform prevention and intervention strategies. This study aims to fill the gap in research regarding these associations, particularly in populations at risk for diabetes.

Data Highlights

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Key Findings

Significant differences in CRF metrics were observed among the Normal Glucose Tolerance, Prediabetes, and Diabetes Mellitus groups.
Maximal VO2/kg was significantly correlated with age, BMI, FPG, HDL-C, VFA, and skeletal muscle mass.
VFA was identified as the strongest negative predictor of maximal VO2/kg.
Skeletal muscle mass served as a positive predictor for maximal VO2/kg.
These findings suggest that body composition metrics are crucial for assessing CRF in populations with abnormal glucose metabolism.

Clinical Implications

Healthcare professionals should consider both CRF and body composition metrics when evaluating patients with varying glucose metabolism statuses. Targeted interventions to improve muscle mass and reduce visceral fat may enhance CRF and mitigate diabetes risk.

Conclusion

The study underscores the importance of assessing CRF and body composition in individuals with different glucose metabolism profiles. These insights can guide clinical strategies aimed at reducing diabetes risk and improving overall health outcomes.