Assessing Natural Health Product-Drug Interactions and Coding Feasibility: Analysis of a New Zealand General Population Dataset from an Online Market Research Panel - Report - MDSpire

Assessing Natural Health Product-Drug Interactions and Coding Feasibility: Analysis of a New Zealand General Population Dataset from an Online Market Research Panel

  • By

  • E Lyn Lee

  • Fraser Ogle

  • Jyadeep Nagra

  • Sofia Su Ye

  • Jeff Harrison

  • Joanne Barnes

  • May 9, 2026

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Evaluating Interactions Between Natural Health Products and Medications

Overview

This study reveals that 71.1% of natural health product (NHP) users in New Zealand concurrently use conventional medicines, highlighting potential safety concerns. The study also identifies challenges in coding NHPs, emphasizing the need for a standardized coding dictionary to enhance monitoring and analysis.

Background

Natural health products (NHPs) are widely used and often self-prescribed, raising safety concerns regarding their interactions with conventional medicines. The prevalence of concurrent use of NHPs and conventional drugs necessitates careful monitoring to prevent adverse drug reactions (ADRs). Despite their perceived safety, serious ADRs linked to NHPs have been documented, underscoring the importance of understanding these interactions.

Data Highlights

No numerical data available.

Key Findings

  • 71.1% of NHP users in New Zealand were concurrently using conventional medicines.
  • Natural health product-drug combinations were identified that may lead to adverse reactions.
  • Approximately one-third of NHPs could not be coded using WHODrug, indicating a need for a standardized coding dictionary.
  • Serious ADRs associated with NHPs, such as hepatotoxicity and increased bleeding risk, have been reported.
  • Effective monitoring of NHP use requires consistent data collection and coding.

Clinical Implications

Healthcare professionals should be aware of the high prevalence of concurrent NHP and conventional medicine use among patients. It is crucial to inquire about NHP use during consultations to mitigate potential adverse drug reactions and ensure patient safety.

Conclusion

The findings underscore the necessity for improved monitoring and coding of NHPs to safeguard public health. Enhanced awareness and communication about NHP use among healthcare providers can help prevent adverse interactions.

References

  1. Drugs - Real World Outcomes, 2025 -- Utilization Trends and Frequency of Natural Health Products and Medicines in New Zealand: Insights from a Pilot Online Market Research Study
  2. Drugs - Real World Outcomes, 2023 -- Investigating the Role of Traditional Remedies, Natural Health Products, and Standard Medications: Creation and Evaluation of the New Zealand 'All-MedsNZ' Survey
  3. Drug Safety, 2021 -- Public Attitudes Toward Leveraging Social Media Data for Enhanced Adverse Drug Reaction Reporting: A Mixed-Methods Investigation
  4. Drugs - Real World Outcomes, 2015 -- Impact of Potentially Inappropriate Medication on Fall-Related Hospitalizations and Primary Care Engagement Among Older Adults in New Zealand: A Population-Based Analysis Utilizing the Updated 2012 Beers Criteria
  5. Categorisation of Products, Medsafe -- Regulatory Guidelines for Medicines
  6. Herb-Drug Interactions | NCCIH
  7. When your patient asks about cannabidiol | Clinical Phytoscience
  8. Categorisation of Products
  9. Herb-Drug Interactions | NCCIH
  10. When your patient asks about cannabidiol | Clinical Phytoscience | Springer Nature Link

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