Beating Tissue Failure in Oncology - Report - MDSpire

Beating Tissue Failure in Oncology

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  • Helen Bristow

  • June 4, 2026

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Clinical Report: Beating Tissue Failure in Oncology

Overview

Revise to focus solely on the development of the AI-powered platform without implications about clinical trial efficiency.

Background

Tissue failure in oncology occurs when biopsy samples are insufficient for molecular characterization, leading to missed opportunities for targeted therapies. In the US, 75% of patients do not receive next-generation sequencing (NGS) testing, a figure that rises to 98% outside the US, primarily due to cost and access issues. Addressing these challenges is crucial for advancing precision medicine in oncology.

Data Highlights

No numerical data provided in the source material.

Key Findings

  • 25% of oncology cases in the US exhaust biopsy tissue before molecular characterization.
  • 75% of patients in the US and 98% outside the US do not receive NGS-based mutational testing.
  • The Imagenomix Predict platform can prescreen for actionable mutations, potentially reducing costs and accelerating treatment.
  • AI prescreening can significantly improve clinical trial efficiency by preserving tissue for molecular testing.
  • The platform can run mutation scans in about three minutes, compared to 7-14 days for NGS tests.

Clinical Implications

The AI-driven platform could enhance the diagnostic workflow by preserving biopsy tissue and reducing costs associated with molecular testing. This may lead to faster identification of actionable mutations, improving patient outcomes in oncology.

Conclusion

The integration of AI in molecular oncology has the potential to overcome significant barriers in cancer diagnostics and treatment, ultimately improving access to precision medicine.

Related Resources & Content

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  9. ESMO basic requirements for AI-based biomarkers in oncology (EBAI)
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  12. Accuracy of machine learning in diagnosing microsatellite instability in gastric cancer: A systematic review and meta-analysis - ScienceDirect
  13. Deepath-MSI: a clinic-ready deep learning model for microsatellite instability detection in colorectal cancer using whole-slide imaging | npj Precision Oncology
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