Peripheral retinal degenerations: multimodal imaging–guided risk stratification and clinical decision-making

By
Siniša Babović
Nemanja Maletin
Nikola Denda

May 13, 2026

Frontiers In Ophthalmology

Overview

This report reviews the risk assessment and clinical management of peripheral retinal degenerations (PRD), emphasizing the role of multimodal imaging techniques. It highlights the importance of differentiating between benign and high-risk lesions to guide appropriate interventions.

Background

Peripheral retinal degenerations (PRD) are common findings during ophthalmic examinations, yet their clinical significance varies widely. Understanding the risk factors associated with PRD is crucial for preventing complications such as retinal tears and rhegmatogenous retinal detachment (RRD). Advances in imaging technology have enhanced the ability to assess these conditions, but the challenge remains in determining which lesions require active management.

Data Highlights

No specific numerical data provided in the source material.

Key Findings

PRD can be categorized into low risk, intermediate, and high risk based on their potential to progress to retinal tears or detachment.
Posterior vitreous detachment (PVD) is a critical factor linking PRD to the development of retinal tears and RRD.
Ultra-widefield (UWF) imaging and swept-source OCT (SS-OCT) enhance the visualization of peripheral retinal structures, aiding in the differentiation of lesion types.
Selective prophylactic laser photocoagulation is recommended for symptomatic retinal tears and certain high-risk configurations, while routine treatment for asymptomatic low-risk PRD is not justified.
AI-assisted decision support may improve risk stratification by integrating imaging features with clinical risk factors.

Clinical Implications

Clinicians should utilize multimodal imaging to accurately assess peripheral retinal degenerations and determine the need for intervention. Individualized management strategies based on risk stratification can help prevent serious complications while avoiding unnecessary treatments for benign lesions.

Conclusion

The management of peripheral retinal degenerations should be guided by a combination of clinical assessment and advanced imaging techniques, focusing on the identification of tractional instability and relevant risk factors.