Proteins at the intersection of circadian rhythms and metabolic dysfunction-associated steatotic liver disease: an 18-protein panel as a novel predictive biomarker set - Report - MDSpire

Proteins at the intersection of circadian rhythms and metabolic dysfunction-associated steatotic liver disease: an 18-protein panel as a novel predictive biomarker set

  • By

  • Yiyi Wang

  • Qilong Zhai

  • Xuemei Lian

  • Lei Zhao

  • May 13, 2026

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Clinical Report: A Novel 18-Protein Panel as Predictive Biomarkers Linking Circadian Rhythm Disruption to Metabolic Dysfunction-Associated Steatotic Liver Disease

Overview

{'add': 'Discuss the relevance of the 18-protein panel compared to existing biomarkers.'}

Background

{'add': 'Expand on the broader implications of circadian rhythm disruption.'}

Data Highlights

{'clarify': 'Define statistical terms like AUC for better understanding.'}

Key Findings

{'add': 'Include a statement on the clinical applicability of the predictive model.'}

Clinical Implications

{'add': 'Provide specific recommendations for clinical assessments.'}

Conclusion

{'add': 'Mention potential future research directions based on findings.'}

References

  1. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Utilizing Machine Learning for the Discovery of Biomarkers Aiding in the Early Detection of Metabolic Dysfunction–Associated Steatotic Liver Disease
  2. Frontiers in Endocrinology, 2023 -- Identification of candidate biomarkers for NAFLD through bioinformatics analysis and machine learning based on circulating insulin degradation-associated genes
  3. Frontiers in Endocrinology, 2023 -- Metabolomic signatures mediate the association between physical frailty and metabolic dysfunction-associated steatotic liver disease: a prospective cohort study
  4. npj Digital Medicine, 2023 -- Combining Multi-Omics Approaches with Machine Learning to Unravel Cellular Diversity and Fibrotic Regulatory Pathways in the Transition from MASLD to MASH
  5. EASL–EASD–EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD), 2024
  6. First FDA-Approved NASH Treatment Produces NASH Resolution and Decreases Fibrosis: Results from the MAESTRO-NASH Trial, American College of Gastroenterology, 2024
  7. Shift work and metabolic dysfunction-associated steatotic liver disease: a systematic review of observational studies, International Archives of Occupational and Environmental Health, 2025
  8. EASL–EASD–EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD) - ScienceDirect
  9. First FDA-Approved NASH Treatment Produces NASH Resolution and Decreases Fibrosis: Results from the MAESTRO-NASH Trial - American College of Gastroenterology
  10. Shift work and metabolic dysfunction-associated steatotic liver disease: a systematic review of observational studies | International Archives of Occupational and Environmental Health | Springer Nature Link

Original Source(s)

Proteins at the intersection of circadian rhythms and metabolic dysfunction-associated steatotic liver disease: an 18-protein panel as a novel predictive biomarker set

  • by Yiyi Wang, Qilong Zhai, Xuemei Lian, Lei Zhao

  • May 13, 2026

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