Recruitment strategies and participant motivations in a digital randomized controlled trial for the prevention of anxiety disorders: the prevANS study - Report - MDSpire

Recruitment strategies and participant motivations in a digital randomized controlled trial for the prevention of anxiety disorders: the prevANS study

  • By

  • Cristina García-Huércano

  • Sonia Conejo-Cerón

  • Alberto Rodríguez-Morejón

  • Carmela Martínez-Vispo

  • Natalia Sánchez-Aguadero

  • Olaya Tamayo-Morales

  • Patricia Moreno-Peral

  • May 13, 2026

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Clinical Report: Strategies for Participant Recruitment in Digital Trials

Overview

The prevANS study evaluated various recruitment strategies for a digital preventive intervention aimed at anxiety disorders, achieving a 17.5% conversion rate from screening to enrollment. Key findings highlighted the effectiveness of social media and university dissemination, as well as participant motivations for enrollment.

Background

Anxiety disorders are highly prevalent and contribute significantly to global disease burden, affecting over 300 million people. Despite effective treatments, many individuals do not receive adequate care due to barriers such as stigma and lack of information. Digital interventions present a scalable solution, but participant recruitment remains a challenge.

Data Highlights

{'Social Media': {'Participants Initiated Screening': 'Specify data', 'Enrollment': 'Specify data', 'Conversion Rate': 'Specify data'}, 'University Dissemination': {'Participants Initiated Screening': 'Specify data', 'Enrollment': 'Specify data', 'Conversion Rate': 'Specify data'}, 'Word of Mouth': {'Participants Initiated Screening': 'Specify data', 'Enrollment': 'Specify data', 'Conversion Rate': 'Specify data'}}

Key Findings

  • The study enrolled 1,054 participants over 26 months, achieving a 17.5% conversion rate.
  • Social media and university dissemination were the most effective recruitment strategies.
  • Word of mouth significantly influenced participant recruitment.
  • The final sample was predominantly women and highly educated individuals.
  • Three main motivations for enrollment included helping others, health-related issues, and personal benefits.

Clinical Implications

Tailoring recruitment strategies to the target population is essential for enhancing enrollment in digital trials. Understanding participant motivations can inform the design of more effective recruitment campaigns.

Conclusion

The prevANS study underscores the importance of strategic recruitment in digital interventions for anxiety prevention, highlighting the need for user involvement in the process.

References

  1. npj Digital Medicine, 2025 -- Internet-based indicated prevention of anxiety and depression disorder onset three-arm randomized clinical trial
  2. BMC Psychiatry, 2025 -- Digital positive affect intervention (PAI) versus self-monitoring placebo in the treatment of anxiety and depression: a two-arm randomized controlled trial (RCT)
  3. BMC Psychiatry, 2026 -- Effectiveness of a Micro-Video Psychological Training Program in Alleviating Depression and Anxiety While Promoting Resilience: A Randomized Controlled Study
  4. npj Digital Medicine, 2026 -- A Randomized Controlled Trial of a Transdiagnostic Online Intervention for Anxiety and Depression in Children and Adolescents
  5. E6(R3) Good Clinical Practice (GCP) | FDA, 2025 -- Guidance on digital recruitment strategies
  6. Recruitment Strategies and Participant Motivations in a Digital Randomized Controlled Trial for the Prevention of Anxiety Disorders: The prevANS Study
  7. E6(R3) Good Clinical Practice (GCP) | FDA
  8. Internet-based indicated prevention of anxiety and depression disorder onset three-arm randomized clinical trial

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