Age and hypoalbuminemia independently predict pulmonary consolidation in children with 23S rRNA A2063G-mutant Mycoplasma pneumoniae pneumonia: a retrospective single-center study - Report - MDSpire

Age and hypoalbuminemia independently predict pulmonary consolidation in children with 23S rRNA A2063G-mutant Mycoplasma pneumoniae pneumonia: a retrospective single-center study

  • By

  • Haiwen Guo

  • Xin Zhang

  • Lirong Luo

  • May 21, 2026

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Independent Risk Factors for Pulmonary Consolidation in Pediatric Patients

Overview

This study identifies older age and lower albumin levels as independent risk factors for pulmonary consolidation in children with 23S rRNA A2063G-variant Mycoplasma pneumoniae pneumonia. The findings underscore the importance of monitoring these factors to improve patient outcomes.

Background

Mycoplasma pneumoniae pneumonia (MPP) is a significant cause of community-acquired pneumonia in children, with the A2063G mutation linked to increased severity and complications. Pulmonary consolidation is a critical complication that can lead to prolonged hospital stays and adverse outcomes. Understanding the risk factors for consolidation is essential for early identification and management of affected pediatric patients.

Data Highlights

CharacteristicMutation PositiveMutation Negative
AgeOlderYounger
Pre-admission coughHigher rateLower rate
Globulin levelsElevatedNormal
Albumin levelsLowerNormal

Key Findings

  • Older age is associated with a higher risk of pulmonary consolidation in MPP patients.
  • Lower albumin levels correlate with increased risk of pulmonary consolidation.
  • Children with the A2063G mutation exhibit higher rates of pre-admission cough and pulmonary consolidation.
  • Increased inflammatory markers such as globulin and various ratios (NLR, MLR, PLR) were observed in mutation-positive children.
  • Children with pulmonary consolidation had longer hospital stays and higher severe pneumonia rates.

Clinical Implications

Clinicians should be vigilant in monitoring older pediatric patients with Mycoplasma pneumoniae pneumonia for signs of pulmonary consolidation, particularly those with lower albumin levels. Early intervention may improve outcomes and reduce the risk of severe complications.

Conclusion

The identification of age and albumin levels as independent risk factors for pulmonary consolidation in children with A2063G-variant MPP highlights the need for targeted monitoring and management strategies in this population.

Related Resources & Content

  1. Frontiers in Pediatrics, 2026 -- Clinical Features and Risk Factors of Plastic Bronchitis in Mycoplasma pneumoniae Pneumonia Children with pulmonary consolidation: A Prospective Cohort Study
  2. Frontiers in Pediatrics, 2026 -- Machine learning-based identification of inflammatory biomarkers for predicting pulmonary consolidation in children with Chlamydia pneumoniae infection
  3. Frontiers in Pediatrics, 2026 -- Construction of a nomogram combining CT and serum markers for predicting macrolide resistance gene mutation status in pediatric Mycoplasma pneumoniae pneumonia
  4. Clinical Rheumatology — Declining Rates of Severe Pneumonia Among Finnish Pediatric Patients with Juvenile Idiopathic Arthritis
  5. IDSA/PIDS pediatric CAP guideline update
  6. A machine learning-based predictive model for multilobar pulmonary consolidation
  7. Frontiers | Risk factors for refractory Mycoplasma pneumoniae in Chinese children: a meta-analysis

Original Source(s)

Age and hypoalbuminemia independently predict pulmonary consolidation in children with 23S rRNA A2063G-mutant Mycoplasma pneumoniae pneumonia: a retrospective single-center study

  • by Haiwen Guo, Xin Zhang, Lirong Luo

  • May 21, 2026

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