Clinical Report: Physical Activity Enhances Communication Between Skeletal Muscle and Heart
Overview
This systematic review highlights the role of skeletal muscle-derived extracellular vesicles (SkM-EVs) and microRNAs (miRNAs) in cardiac aging, emphasizing how exercise can reverse changes associated with aging and sarcopenia. Regular physical activity enhances inter-organ communication.
Background
The intersection of sarcopenia and age-related heart failure poses significant health challenges globally. Understanding the role of skeletal muscle in cardiac health is crucial.
Data Highlights
This review incorporates findings from 51 rigorous in vivo and clinical studies, mapping the SkM-EV and miRNA axis in cardiac aging.
Key Findings
Aging and sarcopenia trigger the release of senescence-associated extracellular vesicles (EVs) that propagate cardiac inflammaging.
Regular exercise stimulates the release of exercise-conditioned EVs enriched with cardioprotective myomiRs.
Muscle-derived miR-34a increases with age and induces senescence in recipient stem cells.
Exercise acts as an epigenetic switch, reversing structural myocardial remodeling.
Targeting the SkM-EV axis may lead to novel liquid biopsies for sarcopenic cardiomyopathy.
Clinical Implications
Understanding the role of SkM-EVs and miRNAs in cardiac aging can inform strategies for managing sarcopenic cardiomyopathy.
Conclusion
This review highlights the role of skeletal muscle in cardiac health and the potential of exercise to improve inter-organ communication.
Shear wave velocity measurements in the basal anteroseptal and right ventricular walls differed between transthyretin and light chain cardiac amyloidosis when conventional echocardiographic parameters did not.
