Non-linear relationship between serum chloride concentrations and all-cause mortality at 30 and 365 days in septic patients with liver cirrhosis - Report - MDSpire

Non-linear relationship between serum chloride concentrations and all-cause mortality at 30 and 365 days in septic patients with liver cirrhosis

  • By

  • Yue Qiu

  • Xiaoqing Liu

  • Hechen Shen

  • Qiao Tang

  • Yunling Xue

  • Peng Hu

  • January 20, 2026

  • 0 min

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Non-linear relationship between serum chloride concentrations and all-cause mortality at 30 and 365 days in septic patients with liver cirrhosis

Overview

This study investigates the non-linear relationship between serum chloride levels and all-cause mortality in septic patients with liver cirrhosis, utilizing data from the MIMIC-IV database. Findings indicate that serum chloride is a significant prognostic marker, with implications for patient management and treatment strategies.

Background

Sepsis is a leading cause of morbidity and mortality, particularly in patients with liver cirrhosis who are at increased risk due to their compromised immune systems. Understanding prognostic indicators like serum chloride can aid in improving outcomes for this vulnerable population. The study highlights the need for effective clinical markers to guide treatment in septic patients with liver cirrhosis.

Data Highlights

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Key Findings

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Clinical Implications

{'content': 'Include specific recommendations for monitoring and management of serum chloride levels.'}

Conclusion

The study underscores the importance of serum chloride as a prognostic indicator in septic patients with liver cirrhosis, suggesting that further research is warranted to optimize management strategies based on chloride levels.

References

  1. Infection, The Relationship Between Serum Osmolality and 28-Day Mortality Rates in Sepsis Patients: Findings from a Retrospective Cohort Analysis, 2024
  2. Intensive Care Medicine, Link Between Intravenous Chloride Administration During Resuscitation and In-Hospital Mortality in Patients with Systemic Inflammatory Response Syndrome, 2014
  3. The Journal of Clinical Endocrinology & Metabolism, Association Between Low Bone Mineral Density and the Risk of Developing Liver Cirrhosis, 2025
  4. Journal of Gastroenterology, Association of Acute Kidney Injury with Mortality in Japanese Cirrhosis Patients: The Role of Amino Acid Imbalance, 2024
  5. Surviving Sepsis Campaign Guidelines 2021 | SCCM, 2021
  6. L-shape association between serum chloride and 365-day mortality in critically ill patients with sepsis based on the MIMIC-IV database, 2026
  7. Surviving Sepsis Campaign Guidelines 2021
  8. L-shape association between serum chloride and 365-day mortality in critically ill patients with sepsis based on the MIMIC-IV database - PMC
  9. Hepatology

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