Implementation of a Golden Hour protocol for initial management of preterm infants: a quality improvement study - Report - MDSpire

Implementation of a Golden Hour protocol for initial management of preterm infants: a quality improvement study

  • By

  • Sarah Dénes

  • Estelle Stockis

  • Vincent Rigo

  • Sophie Tribolet

  • May 20, 2026

  • 0 min

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Clinical Report: Adoption of a Golden Hour Protocol for Preterm Infants

Overview

The implementation of a Golden Hour protocol for preterm infants improved thermal regulation and team efficiency during the first hour of life without adversely affecting clinical outcomes. The protocol led to earlier blood glucose evaluations and reduced instances of hypothermia.

Background

Premature infants face significant risks during their transition to extrauterine life, necessitating prompt and coordinated care. The Golden Hour concept emphasizes the importance of structured interventions in the first hour of life to enhance stabilization and reduce morbidity. Variability in care practices highlighted the need for a standardized approach to improve outcomes in this vulnerable population.

Data Highlights

OutcomeGH Group (n=77)Control Group (n=72)P-value
Hypothermia23360.03
First blood glycemia evaluation (min)43 (35–50)63 (53–77)<0.001
Median incubator closure time (min)64 (58–71)--

Key Findings

  • The Golden Hour protocol reduced hypothermia rates (23/77 vs. 36/72, p=0.03).
  • First blood glucose evaluations were conducted significantly earlier in the GH group (43 min vs. 63 min, p<0.001).
  • The median time to incubator closure was close to the target of 60 minutes (64 min).
  • Rates of hypoglycemia, mortality, and major comorbidities were similar between the GH and control groups.
  • Team members reported improved anticipation, communication, and job satisfaction after protocol implementation.

Clinical Implications

The Golden Hour protocol can be effectively implemented in NICUs to enhance the management of preterm infants during their critical first hour of life. Improved thermal regulation and team dynamics may contribute to better care delivery without compromising clinical outcomes.

Conclusion

The adoption of a Golden Hour protocol demonstrates significant improvements in procedural efficiency and team collaboration, suggesting its potential for broader application in neonatal care settings.

Related Resources & Content

  1. Reynolds et al., Pediatric Cardiology, 2025 -- Navigating the Transition from Uterine Safety to External Environment for Newborns with Severe Cardiovascular Disorders: The IMmediate Postpartum Access to Cardiac Therapy (IMPACT) Approach
  2. Frontiers in Medicine, 2026 -- A Three-Factor Nomogram Predicts the Use of Invasive Mechanical Ventilation within 72 Hours in Preterm Infants
  3. Reynolds et al., Pediatric Cardiology, 2017 -- Implementation of Genetic Testing Guidelines Lowers Expenses and Enhances Diagnostic Rates for Infants with Congenital Heart Defects
  4. Reynolds et al., Pediatric Cardiology, 2025 -- Improved Neonatal Outcomes in Prenatally Diagnosed Congenital Heart Disease Through a Standardized Clinical Assessment and Management Strategy
  5. American Heart Association, 2025 -- Part 5: Neonatal Resuscitation
  6. 2025 CoSTR Summary: Neonatal Life Support
  7. Part 5: Neonatal Resuscitation | American Heart Association CPR & First Aid

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