Exercise interventions for depressive symptoms in adults with lung and digestive cancer: a meta-analysis of randomized controlled trials - Report - MDSpire

Exercise interventions for depressive symptoms in adults with lung and digestive cancer: a meta-analysis of randomized controlled trials

  • By

  • Xiao-xia Shang

  • Miao Liu

  • Wei-ming Yang

  • Zheng Zhang

  • June 1, 2026

  • 0 min

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Clinical Report: Impact of Exercise Programs on Depression in Cancer Patients

Overview

This meta-analysis evaluates the effects of exercise interventions on depressive symptoms in adults with lung and gastrointestinal cancers. The findings suggest that exercise significantly reduces depressive symptoms, highlighting its potential as an adjunctive strategy in psychological care for these patients.

Background

Depressive symptoms are prevalent among cancer patients, adversely affecting their quality of life and treatment adherence. This issue is particularly pronounced in patients with lung and digestive cancers, who often experience high symptom burdens and emotional distress. Understanding effective non-pharmacological interventions, such as exercise, is crucial for improving mental health outcomes in these populations.

Data Highlights

OutcomeEffect Size (SMD)P-value
Depressive Symptoms-0.450.02

Key Findings

  • Exercise significantly reduced depressive symptoms compared to control conditions (SMD = -0.45, P = 0.02).
  • No significant difference in depressive symptoms was observed between groups at baseline.
  • Substantial heterogeneity was noted in the results.
  • Individually delivered programs and walking-based exercises showed numerically larger effect estimates.
  • Moderate-frequency training (3–5 times per week) may be associated with greater benefits.

Clinical Implications

Healthcare providers should consider incorporating structured exercise programs into the care plans for patients with lung and digestive cancers to help alleviate depressive symptoms. Tailoring exercise interventions based on individual patient characteristics may enhance their effectiveness.

Conclusion

Exercise interventions represent a promising approach to reducing depressive symptoms in adults with lung and digestive cancers, warranting further research to optimize exercise prescriptions for this population.

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  4. NCCN Guidelines® Insights: Survivorship, Version 2.2025 - PubMed
  5. Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update | Journal of Clinical Oncology
  6. Impact of Depression and Anxiety on Mortality in Colorectal Cancer: A Systematic Review and Meta-Analysis of Univariate and Multivariate Findings
  7. American Cancer Society Guideline for Diet and Physical Activity for Cancer Survivors
  8. ESMO Clinical Practice Guideline Express Update on the adoption of physical exercise in patients with localised colon cancer
  9. NCCN Guidelines® Insights: Survivorship, Version 2.2025 - PubMed
  10. Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update | Journal of Clinical Oncology
  11. Structured Exercise after Adjuvant Chemotherapy for Colon Cancer - PubMed
  12. A randomized phase III trial of the impact of a structured exercise program on disease-free survival (DFS) in stage 3 or high-risk stage 2 colon cancer: Canadian Cancer Trials Group (CCTG) CO.21 (CHALLENGE). | Journal of Clinical Oncology
  13. Frontiers | Exercise Interventions for Depressive Symptoms in Adults with Lung and Digestive Cancer: A Meta-Analysis of Randomized Controlled Trials
  14. Exercise effects on symptoms of depression and anxiety vary by patient, clinical, and intervention characteristics in cancer survivors: Results from pooled analyses of individual participant data of 26 RCTs | Supportive Care in Cancer | Springer Nature Link
  15. Comparison of the efficacy of exercise interventions on depressive and anxiety symptoms in cancer patients: A systematic review and network meta-analysis - PubMed
  16. Nurse-supported hybrid home-based pulmonary rehabilitation improves psychological distress, quality of life, and functional performance in advanced lung cancer: A randomized controlled trial - PubMed
  17. Effects of Exercise on Depression and Anxiety in Lung Cancer Survivors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - PMC

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