A hybrid implementation-effectiveness study of a school-based intervention for promoting health and well-being in low-resource settings: the ISOBAR study protocol - Report - MDSpire

A hybrid implementation-effectiveness study of a school-based intervention for promoting health and well-being in low-resource settings: the ISOBAR study protocol

  • By

  • Swaran P. Singh

  • Catherine Winsper

  • Nadia Binte Alam

  • Tolulope Bella-Awusah

  • Graeme Currie

  • Oluwabunmi (Tokun) Fola-Bolumole

  • Domenico Giacco

  • Paramjit Gill

  • Sanjana Goutham

  • Srividya N. Iyer

  • Jasmine Kalha

  • Isha Lohumi

  • Jason Madan

  • Dafne Moroni

  • Olayinka Omigbodun

  • Soumitra Pathare

  • Shiva Prakash Srinivasan

  • Simon Smith

  • J.S. Thakur

  • Thara Rangaswamy

  • Helena Tuomainen

  • Samuel Watson

  • Sagar Jilka

  • July 14, 2026

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Clinical Report: A Hybrid Study Protocol for Assessing the ISOBAR Project

Overview

The ISOBAR project aims to develop and evaluate a culturally adapted school-based health intervention targeting mental and physical health issues among adolescents in resource-limited settings. The study will assess the effectiveness, implementation processes, and cost-effectiveness of the intervention across multiple sites in India and Nigeria.

Background

Adolescence is a critical period for the development of non-communicable diseases (NCDs), which are increasingly affecting younger populations in low-and-middle-income countries (LMICs). School-based interventions can effectively promote healthy behaviors and improve health outcomes, yet many existing models lack cultural adaptation and focus on implementation. The ISOBAR project seeks to address these gaps through a structured intervention.

Data Highlights

The ISOBAR project will involve 1,800 adolescents across nine schools, assessing mental and physical health at baseline and evaluating the intervention's impact on health outcomes.

Key Findings

  • The ISOBAR intervention consists of three stages: assessment, health literacy, and counselling.
  • It will be implemented in a staggered roll-out across three sites in India and Nigeria.
  • Local teams will recruit 200 adolescents per school for a total of 1,800 participants.
  • All participants will be assessed for mental health and nutritional problems at baseline.
  • Ethical considerations prevent a randomized controlled trial, limiting causal inference.
  • Control condition students will receive guidance to local services.

Clinical Implications

The ISOBAR project highlights the importance of culturally adapted interventions in addressing adolescent health issues in LMICs. It emphasizes the need for comprehensive assessments and the integration of health literacy and counselling in school-based programs.

Conclusion

The ISOBAR project represents a significant effort to develop a tailored health intervention for adolescents in resource-limited settings, with the potential to inform future health promotion strategies.

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