Clinical Report: Assessment of ALA-PDT for HPV-Related CIN I

Overview

This study evaluates the effectiveness and safety of aminolevulinic acid photodynamic therapy (ALA-PDT) for treating HPV-associated cervical intraepithelial neoplasia grade I (CIN I).

Background

Cervical intraepithelial neoplasia (CIN) is closely linked to HPV infection, particularly high-risk types such as HPV16 and HPV18. Current treatment options for CIN have limitations, including complications and varying efficacy.

Data Highlights

Key Findings

• 240 patients diagnosed with CIN I were enrolled in the study.
• Group B2 (5-hour application, 40-minute light exposure) showed the highest cure rate and lowest recurrence rate (P<0.05).
• HPV positivity rates decreased significantly at 3 and 6 months post-treatment across all groups.
• Significant reductions in HPV16 and HPV18 types were observed, particularly in Group B2.
• No significant differences in progression rates or adverse reactions were noted across groups (P>0.05).
• HPV16 and HPV18 were positively correlated with the cure rate (correlation coefficients of 0.432 and 0.421, respectively; P<0.05).

Clinical Implications

Clinicians may consider ALA-PDT as a treatment option for CIN I.

Conclusion

ALA-PDT demonstrates effectiveness in treating HPV-associated CIN I.

Related Resources & Content

1. Frontiers in Medicine, 2026 -- Efficacy of 5-aminolevulinic acid photodynamic therapy for the treatment of female lower reproductive tract intraepithelial lesions and its predictive biomarker: DNA methylation
2. Assessing the Effectiveness of Various Treatments for Anal Intraepithelial Neoplasia: A Comprehensive Review
3. Frontiers in Surgery, 2026 -- Intralesional ALA-PDT for residual extramammary Paget's disease: a case report
4. 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors - PMC
5. Efficacy of ALA‐PDT in treating cervical low‐grade squamous intraepithelial lesions with high‐risk HPV patients: A multicentre randomized controlled trial - International Journal of Cancer, 2025
6. Techniques in Coloproctology — Guidelines for Clinical Practice in Screening Precancerous Anal Lesions Associated with Human Papillomavirus in France
7. 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors - PMC
8. Efficacy of ALA‐PDT in treating cervical low‐grade squamous intraepithelial lesions with high‐risk HPV patients: A multicentre randomized controlled trial - Wei - 2025 - International Journal of Cancer - Wiley Online Library
9. Effect of Clinicopathological Characteristics on the Outcomes of Topical 5-Aminolevulinic Acid Photodynamic Therapy in Patients with Cervical High-Grade Squamous Intraepithelial Lesions (HSIL/CIN2): A Retrospective Cohort Study - PMC