Clinical Characteristics and Serum HDL-C Are Associated with Adverse Prognosis in Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction at Admission - Report - MDSpire
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Clinical Characteristics and Serum HDL-C Are Associated with Adverse Prognosis in Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction at Admission
Association of Clinical Features and Serum HDL-C Levels with Poor Outcomes in Patients with Acute Decompensated Heart Failure and Preserved Ejection Fraction at Admission
Overview
This study investigates the relationship between clinical characteristics, lipid metabolism parameters, and prognosis in patients with acute decompensated heart failure (HF) with preserved ejection fraction (HFpEF).
Background
Acute decompensated heart failure (ADHF) is a leading cause of hospitalization and is associated with significant morbidity and mortality. Understanding the clinical and biochemical predictors of adverse outcomes in patients with HFpEF is important.
Data Highlights
Parameter
HFpEF (n=73)
HFrEF (n=85)
Palpitations/Angina
Significant
Significant
Cough
Significant
Significant
Highest Systolic BP
Significant
Significant
Total Cholesterol
Significant
Significant
HDL-C
Significant
Significant
Key Findings
High levels of HDL-C are associated with a lower risk of adverse cardiovascular events (OR = 0.265, p = 0.038).
Clinical symptoms such as palpitations, cough, and psychological distress differ significantly between HFpEF and HFrEF patients.
Both HFpEF and HFrEF groups show significant differences in blood pressure and lipid profiles.
The AUC for HDL-C in predicting prognosis is 0.611 (p = 0.021).
Clinical Implications
Clinicians should consider HDL-C levels as a potential prognostic marker in patients with acute decompensated heart failure, particularly in those with preserved ejection fraction. Monitoring clinical symptoms and lipid profiles may enhance risk stratification and management strategies.
Conclusion
The study highlights the association of clinical features and HDL-C levels with adverse outcomes in acute decompensated heart failure patients.
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