Assessment of Glucose Disposal Rate Changes and the Onset of Cardiovascular Disease in Patients with Stages 0–3 of Cardiovascular–Kidney–Metabolic Syndrome: A Prospective Cohort Analysis from China

By
Jia Liu
Wendong Xu
Yue Zhang
Yuan Jia
Shiru Bai
Lu Er
Rongpin Du
November 26, 2025
0 min

Bmc Cardiovascular Disorders

Overview

This study investigates the relationship between changes in estimated glucose disposal rate (eGDR) and the onset of cardiovascular disease (CVD) in patients with cardiovascular–kidney–metabolic syndrome (CKM) stages 0–3. Findings suggest that dynamic eGDR trajectories are significant predictors of new-onset CVD in this population.

Background

Cardiovascular–kidney–metabolic syndrome (CKM) represents a critical public health challenge, particularly in China, where CVD is a leading cause of mortality. Early identification and intervention for individuals with CKM stages 0–3 are essential to mitigate the risk of CVD, yet traditional risk assessment models often fall short. The study highlights the potential of eGDR as a more accessible marker for insulin resistance and its implications for cardiovascular risk stratification.

Data Highlights

Parameter	Findings
eGDR Measurement	Dynamic changes associated with CVD risk
Population	Chinese adults with CKM stages 0-3
Study Design	Prospective cohort analysis

Key Findings

Dynamic eGDR changes are linked to new-onset CVD in CKM patients.
Higher baseline eGDR correlates with lower CVD risk.
Long-term exposure to low eGDR levels increases CVD risk.
eGDR is a more practical marker for insulin resistance compared to HOMA-IR.
CKM syndrome stages 0-3 often present without symptoms, necessitating proactive monitoring.

Clinical Implications

Healthcare professionals should consider monitoring eGDR in patients with CKM syndrome to better assess cardiovascular risk. Early intervention strategies targeting insulin resistance may help prevent the onset of CVD in this high-risk population.

Conclusion

The study underscores the importance of dynamic eGDR assessment in predicting cardiovascular risk among patients with CKM syndrome, advocating for its integration into routine clinical practice for improved patient outcomes.