Identification of patients at risk for poor survival among those with normal skeletal muscle mass: a multicenter retrospective validation study in gastric cancer - Report - MDSpire

Identification of patients at risk for poor survival among those with normal skeletal muscle mass: a multicenter retrospective validation study in gastric cancer

  • By

  • Ryota Matsui

  • Kazuyoshi Yamamoto

  • Yoshiro Yukawa

  • Masayoshi Terayama

  • Yukinori Kurokawa

  • Daisuke Ichikawa

  • Yoshitomo Yanagimoto

  • Takashi Oshima

  • Souya Nunobe

  • Takashi Kamei

  • Hiroya Takeuchi

  • Yoshihiro Nabeya

  • Masaki Kaibori

  • Naoki Hiki

  • Hidetoshi Eguchi

  • Yuichiro Doki

  • July 6, 2026

  • 0 min

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Clinical Report: Assessing Survival Risks in Gastric Cancer Patients

Overview

This study investigates the cutoff value for skeletal muscle mass index (SMI) that predicts poor long-term survival in gastric cancer patients without low skeletal muscle mass.

Background

Low skeletal muscle mass is associated with adverse postoperative outcomes in gastric cancer patients. As the population ages, the prevalence of low skeletal muscle mass is expected to rise.

Data Highlights

No numerical data provided in the source material.

Key Findings

  • Low skeletal muscle mass is linked to poor postoperative outcomes and long-term survival in gastric cancer patients.
  • The study aims to determine the cutoff value for SMI that predicts poor survival in patients without low skeletal muscle mass.
  • Patients without preoperative sarcopenia who develop postoperative sarcopenia have poorer long-term survival.
  • The study was conducted across 17 hospitals in Japan, focusing on patients who underwent radical gastrectomy.

Clinical Implications

Understanding the cutoff values for SMI can aid clinicians in identifying gastric cancer patients at risk for poor outcomes post-surgery.

Conclusion

Determining the appropriate SMI cutoff values is crucial for improving prognostic assessments in gastric cancer patients.

Related Resources & Content

  1. Muscle Mass and Sarcopenia Do Not Serve as Prognostic Indicators for Outcomes Following Esophagectomy in Cancer Patients, Springer, 2016 -- Title
  2. Skeletal Muscle Index Serves as a Standalone Indicator for Early Recurrence in Non-Obese Patients with Colon Cancer, Springer, 2020 -- Title
  3. Body Composition as a Predictor of Postoperative Complications Following Gastrectomy in Gastric Cancer Patients: Insights from a Prospective Substudy of the LOGICA Trial, Journal of Gastrointestinal Surgery -- Title
  4. Clinical Implications of Serum Inflammatory Biomarkers in Gastric Cancer Prognosis, Journal of Gastrointestinal Surgery, 2017 -- Title
  5. ESPEN guideline on clinical nutrition in surgery – Update 2025, ESPEN -- Title
  6. Postoperative skeletal muscle loss as a prognostic indicator of clinical outcomes in patients with gastric cancer: a systematic review and meta-analysis, PubMed -- Title
  7. The impact of preoperative skeletal muscle mass index-defined sarcopenia on postoperative complications and survival in gastric cancer: An updated meta-analysis, PubMed -- Title
  8. ESPEN guideline on clinical nutrition in surgery – Update 2025
  9. Postoperative skeletal muscle loss as a prognostic indicator of clinical outcomes in patients with gastric cancer: a systematic review and meta-analysis - PubMed
  10. The impact of preoperative skeletal muscle mass index-defined sarcopenia on postoperative complications and survival in gastric cancer: An updated meta-analysis - PubMed

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