The efficacy of acupuncture for depression-associated chronic pain: a systematic review and meta-analysis - Report - MDSpire

The efficacy of acupuncture for depression-associated chronic pain: a systematic review and meta-analysis

  • By

  • Hui Zhao

  • Yuan Gao

  • Kun Zhang

  • Cheng Tang

  • Weidong Shen

  • June 1, 2026

  • 0 min

Share

Clinical Report: Assessing Acupuncture's Effectiveness in Managing Chronic Pain

Overview

Revise to accurately reflect that acupuncture combined with conventional medications shows effectiveness, but does not claim superiority over all measures.

Background

Chronic pain and depression frequently co-occur, complicating treatment strategies and negatively impacting patient quality of life. The high prevalence of depression among chronic pain patients necessitates effective management strategies that address both conditions. Acupuncture is being explored as a potential adjunctive therapy in this context.

Data Highlights

OutcomeStandardized Mean Difference (SMD)95% Confidence Interval (CI)P-value
Depressive Symptoms-0.72-0.91 to -0.53< 0.01
Pain Reduction-0.85-1.36 to -0.34< 0.01
Hamilton Depression Rating Scale-0.05-0.61 to 0.51> 0.05
Visual Analogue Scale-0.33-0.94 to 0.29> 0.05
Safety Profile (Relative Risk)0.400.27 to 0.60N/A

Key Findings

Remove or rephrase the point about 4-week treatment being more effective, as it suggests a definitive conclusion not supported by the source.

Clinical Implications

Remove unsupported claims about acupuncture as an adjunctive therapy and recommendations for treatment duration.

Conclusion

Revise to avoid unsupported claims about promise and safety enhancement; focus on findings directly from the source.

Related Resources & Content

  1. Frontiers in Neurology, 2026 -- A meta-analysis of neuroimaging evidence for acupuncture-mediated modulation of altered central pain processing in patients with chronic pain
  2. Frontiers in Oncology, 2026 -- Effectiveness of acupuncture for cancer-related fatigue: a systematic reviews and meta-analysis
  3. Frontiers in Neurology, 2026 -- Acupuncture effects on non-motor symptoms of Parkinson’s disease (sleep, mood, and fatigue): a systematic review and meta-analysis
  4. Frontiers in Neurology, 2026 -- Effectiveness and safety of skull base-peripheral acupuncture for post-stroke cognitive impairment: a systematic review and meta-analysis of randomized controlled trials
  5. NICE, 2022 -- Overview | Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain
  6. PubMed, 2025 -- Acupuncture for Chronic Low Back Pain in Older Adults: A Randomized Clinical Trial
  7. Overview | Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain | Guidance | NICE
  8. Acupuncture for Chronic Low Back Pain in Older Adults: A Randomized Clinical Trial - PubMed

Original Source(s)

Related Content