CCR1-mediated monocyte chemotaxis in the immunopathology of primary Sjögren’s syndrome: multi-omics integration analysis and computational target prioritization implicating Polygonatum odoratum - Report - MDSpire
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Investigating CCR1's Role in Monocyte Migration within the Immunopathology of Primary Sjögren’s Syndrome: A Multi-Omics Approach and Computational Analysis Highlighting Polygonatum odoratum as a Potential Therapeutic Target
Clinical Report: Investigating CCR1's Role in Monocyte Migration in pSS
Overview
This study explores the role of CCR1 in the immunopathology of primary Sjögren’s syndrome (pSS). Findings indicate that CCR1 is significantly upregulated in pSS patients and is associated with monocyte recruitment and immune dysregulation.
Background
Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, leading to significant morbidity. The disease has a complex pathogenesis involving immune dysregulation and increased risk of non-Hodgkin lymphoma. Current treatments are largely symptomatic.
Data Highlights
Parameter
Value
AUC for CCR1
0.758
Correlation with serum IgG levels
R = 0.49, P = 0.0057
Expansion of CCR1-positive monocytes in pSS
P = 0.0079
RT-qPCR confirmation of CCR1 expression
P < 0.0001
Key Findings
CCR1 was identified as a candidate target for pSS, being drug-targetable, disease-related, and differentially expressed.
CCR1 expression was significantly higher in pSS patients compared to healthy controls.
CCR1-positive monocytes were expanded in pSS, particularly in classical monocytes.
Single-cell analysis indicated a potential CCL5–CCR1-mediated monocyte recruitment signaling axis.
Moupinamide from Polygonatum odoratum showed predicted binding affinity to CCR1.
Clinical Implications
The association of CCR1 with monocyte recruitment highlights its potential role in the disease's immunopathology.
Conclusion
This study provides evidence for CCR1's involvement in pSS.
