Clinical Report: Withdrawal of Study on Immune-Related Genes in SLE and DLBCL

Overview

The article discussing machine-learning insights into immune-related genes in systemic lupus erythematosus (SLE) and their influence on apoptosis and cell cycle dynamics in diffuse large B-cell lymphoma (DLBCL) has been withdrawn. An investigation revealed discrepancies that rendered the data and conclusions unreliable.

Background

Systemic lupus erythematosus is a complex autoimmune disorder that can lead to various complications, including an increased risk of non-Hodgkin lymphoma, particularly DLBCL. Understanding the molecular mechanisms underlying these associations is crucial.

Data Highlights

No numerical or trial data is available due to the withdrawal of the study.

Key Findings

• The article was retracted due to concerns about scientific integrity.
• Indicators of third-party involvement were identified during the investigation.
• The peer review process was deemed inadequate.
• The authors' provided data did not resolve the discrepancies under investigation.
• The conclusions drawn in the article are considered unreliable.

Clinical Implications

Healthcare professionals should remain cautious when interpreting findings from studies that have not undergone thorough validation.

Conclusion

The withdrawal of this article highlights the necessity for maintaining high standards in scientific research.

Related Resources & Content

1. Ruan, S., Wang, S., Jiang, Y., Frontiers in Medicine, 2025 -- Withdrawal of Study: Insights from Machine Learning Indicate Immune-Related Genes in Systemic Lupus Erythematosus Influence Apoptosis and Cell Cycle Dynamics in Diffuse Large B-Cell Lymphoma
2. Frontiers in Immunology — Integrative plasma proteomics and myeloid- interferon profiling reveal an AI-validated vascular- endothelial stress signature distinguishing SLE flare from remission in an Indian cohort a discovery – phase study
3. Frontiers in Immunology — Immune regulation and cell metabolism in B cell subsets in patients with systemic lupus erythematosus
4. ACR Open Rheumatology — Reproducible Molecular Subtypes in Systemic Lupus Erythematosus Are Associated With Disease Activity, Serology, and Distinct Trajectories Over Time
5. Arthritis & Rheumatology — T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large-Scale T Cell Receptor Repertoire and Transcriptome Studies
6. Five-Year Outcomes of the POLARIX Study Comparing Pola-R-CHP and R-CHOP in Patients With Diffuse Large B-Cell Lymphoma | Journal of Clinical Oncology
7. 2026 Update on the Management of Diffuse Large B‐Cell Lymphoma - PMC
8. Environmental risk factors for non-Hodgkin's lymphoma: umbrella review and comparison of meta-analyses of summary and individual participant data - PMC