Incidence and case fatality of aneurysmal subarachnoid hemorrhage admitted to hospital between 2008 and 2014 in Norway - Report - MDSpire

Incidence and case fatality of aneurysmal subarachnoid hemorrhage admitted to hospital between 2008 and 2014 in Norway

  • By

  • Lise R. Øie

  • Ole Solheim

  • Paulina Majewska

  • Trond Nordseth

  • Tomm B. Müller

  • Sven M. Carlsen

  • Heidi Jensberg

  • Øyvind Salvesen

  • Sasha Gulati

  • June 30, 2020

  • 0 min

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Clinical Report: Incidence and Mortality of Aneurysmal SAH in Norway 2008–2014

Overview

This study analyzed national data from Norway between 2008 and 2014 to determine the incidence and mortality rates of aneurysmal subarachnoid hemorrhage (aSAH). Findings indicate a modest decline in incidence rates and provide detailed mortality statistics at 30, 90, and 365 days post-admission, along with predictors of early death.

Background

Aneurysmal subarachnoid hemorrhage (aSAH) accounts for about 5% of all strokes and is associated with high morbidity and mortality. It predominantly affects individuals in their 40s to 60s and is most commonly caused by ruptured intracranial aneurysms. Established risk factors include hypertension, smoking, and alcohol abuse. Although overall stroke incidence has declined due to better risk factor management, the reduction in aSAH incidence has been relatively modest. Accurate epidemiological data are essential for understanding trends and improving outcomes.

Data Highlights

ParameterValue
Study Period2008–2014
PopulationAdults ≥18 years in Norway (3.6–4.0 million)
Incidence RateCalculated per 100,000 person-years
Case Fatality RatesReported at 30, 90, and 365 days post-admission
Diagnosis Confirmation Rate95.3% for SAH ICD-10 codes

Key Findings

  • The incidence of aSAH in Norway showed a modest decline from 2008 to 2014.
  • Case fatality rates were calculated at 30, 90, and 365 days, demonstrating mortality trends post-aSAH.
  • Female gender and older age were associated with increased risk of aneurysm rupture and mortality.
  • Hypertension and smoking remain key modifiable risk factors influencing aSAH incidence.
  • Data were derived from comprehensive national registries ensuring high completeness and accuracy.
  • Cox proportional hazard modeling identified predictors of early death following aSAH.

Clinical Implications

Clinicians should continue to focus on controlling modifiable risk factors such as hypertension and smoking to potentially reduce aSAH incidence. Awareness of demographic risk factors can aid in risk stratification and early intervention. The national registry data support the importance of systematic surveillance to monitor trends and outcomes in aSAH.

Conclusion

This nationwide Norwegian study provides valuable epidemiological insights into aSAH incidence and mortality, highlighting a modest decline in incidence and identifying key predictors of early mortality. Continued public health efforts targeting risk factor modification are essential to further reduce the burden of aSAH.

References

  1. Norwegian Patient Registry and Prescription Database Data, 2008–2014 -- Hospital Admissions for Aneurysmal Subarachnoid Hemorrhage

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