As a scientist and NFL widow, I am furious about a recent NFL Players Association-funded CTE study - Report - MDSpire

As a scientist and NFL widow, I am furious about a recent NFL Players Association-funded CTE study

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  • Eleanor M. Perfetto

  • February 7, 2026

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Clinical Report: Outrage Over NFLPA-Funded CTE Study Findings

Overview

A recent study funded by the NFL Players Association claims increased suicide rates among NFL players may be linked to heightened awareness of chronic traumatic encephalopathy (CTE). However, significant methodological flaws raise concerns about the validity of these findings and their implications for understanding CTE.

Background

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease associated with repeated head trauma, particularly in contact sports like football. The implications of CTE are profound, affecting cognitive function and quality of life for former athletes. Awareness and understanding of CTE are crucial for prevention and management strategies, especially given the high prevalence of the disease among former NFL players.

Data Highlights

The study identified 66 suicides among NFL players over a 40-year period, but the statistical significance of the findings is questionable due to methodological limitations.

Key Findings

  • The study claims a 2.6-fold increase in NFL player suicide rates from 1979-2010 to 2011-2019.
  • Methodological flaws include the use of multiple comparisons, which may inflate the likelihood of false-positive results.
  • Comparison of NFL players to MLB players showed no significant difference in suicide rates.
  • Broader societal factors, such as increased access to firearms, were not considered in the analysis.
  • Over 90% of studied former NFL players' brains exhibited signs of CTE, highlighting the disease's prevalence.

Clinical Implications

Healthcare professionals should remain vigilant about the implications of CTE in former athletes and advocate for comprehensive research that accurately reflects the complexities of the disease. It is essential to address the mental health needs of former players while also promoting awareness of CTE's serious consequences.

Conclusion

The findings from the NFLPA-funded study warrant skepticism due to significant methodological issues, underscoring the need for rigorous research in understanding CTE and its impact on former athletes.

References

  1. Acta Neuropathologica, 2023 -- Chronic Traumatic Encephalopathy (CTE): Neuropathological Diagnostic Criteria and Its Connection to Repeated Head Trauma
  2. Acta Neuropathologica, 2017 -- First Documented Instance of Chronic Traumatic Encephalopathy in a Professional Bull Rider
  3. Acta Neuropathologica, 2023 -- Risks Associated with Contact Sports: Neurodegenerative Changes and Diffuse Brain Swelling Observed in a 23-Year-Old Rugby Player
  4. Acta Neuropathologica, 2023 -- Association Between Playing Career Duration and Chronic Traumatic Encephalopathy Risk in Rugby Union Athletes

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