HLA matching in contemporary haematopoietic cell transplantation: Recommendations from the EBMT Practice Harmonisation and Guidelines Committee - Report - MDSpire

HLA matching in contemporary haematopoietic cell transplantation: Recommendations from the EBMT Practice Harmonisation and Guidelines Committee

  • By

  • Esteban Arrieta-Bolaños

  • Alberto Cardoso Martins Lima

  • Marco Andreani

  • Dianne De Santis

  • Florent Malard

  • Neema P. Mayor

  • Rohtesh S. Mehta

  • Roland Meisel

  • Simona Pagliuca

  • Effie Petersdorf

  • Simona Piemontese

  • Nicoletta Sacchi

  • Nicole Santoro

  • Jaime Sanz

  • Johannes Schetelig

  • Stephen R. Spellman

  • Francesco Onida

  • Isabel Sánchez-Ortega

  • Mohamad Mohty

  • Ibrahim Yakoub-Agha

  • Katharina Fleischhauer

  • Annalisa Ruggeri

  • June 2, 2026

  • 0 min

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Current Recommendations for HLA Compatibility in Hematopoietic Cell Transplantation

Overview

Revise to include specific examples of novel GvHD prophylaxes and their impact on HLA mismatches.

Background

HLA compatibility is critical for the success of allogeneic HCT, as mismatched transplants are often linked to poorer survival outcomes. Recent advancements in HLA typing and GvHD management necessitate a reevaluation of traditional beliefs regarding HLA mismatches. Understanding these dynamics is essential for optimizing donor selection and improving patient outcomes in HCT.

Data Highlights

No specific numerical data provided in the source material.

Key Findings

Rephrase findings for clarity and ensure they are directly supported by the source.

Clinical Implications

Clinicians should consider both HLA and non-HLA factors when selecting donors for HCT to enhance patient outcomes. The integration of novel GvHD prophylaxes like PTCy may allow for more flexible donor matching strategies, potentially improving survival rates in mismatched cases.

Conclusion

The evolving landscape of HLA compatibility in HCT underscores the need for updated clinical guidelines that reflect contemporary practices and technologies. Ongoing research and consensus recommendations will continue to shape effective donor selection strategies.

Related Resources & Content

  1. EBMT/ESID Working Group, Bone Marrow Transplantation, 2021 -- Guidelines for Hematopoietic Stem Cell Transplantation for Inborn Errors of Immunity
  2. EBMT, Bone Marrow Transplantation, 2025 -- Guidelines for Hematopoietic Cell Transplantation and CAR-T Therapy
  3. EBMT, Bone Marrow Transplantation, 2022 -- Current Guidelines for Hematopoietic Cell Transplantation
  4. The ASCO Post, 2025 -- HLA-Matching Considerations for Hematopoietic Cell Transplantation
  5. NMDP/CIBMTR, PMC -- Allogeneic Hematopoietic Cell Donor Selection: Contemporary Guidelines
  6. Allogeneic Hematopoietic Cell Donor Selection: Contemporary Guidelines from the NMDP/CIBMTR
  7. Matched unrelated vs haploidentical donor hematopoietic cell transplantation using posttransplant cyclophosphamide

Original Source(s)

HLA matching in contemporary haematopoietic cell transplantation: Recommendations from the EBMT Practice Harmonisation and Guidelines Committee

  • by Esteban Arrieta-Bolaños, Alberto Cardoso Martins Lima, Marco Andreani, Dianne De Santis, Florent Malard, Neema P. Mayor, Rohtesh S. Mehta, Roland Meisel, Simona Pagliuca, Effie Petersdorf, Simona Piemontese, Nicoletta Sacchi, Nicole Santoro, Jaime Sanz, Johannes Schetelig, Stephen R. Spellman, Francesco Onida, Isabel Sánchez-Ortega, Mohamad Mohty, Ibrahim Yakoub-Agha, Katharina Fleischhauer, Annalisa Ruggeri

  • June 2, 2026

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