Link Between the C-Reactive Protein-Triglyceride-Glucose Index and Major Adverse Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention

Overview

This study evaluates the association between the C-reactive protein-triglyceride-glucose index (CTI) and major adverse cardiovascular events (MACEs) in patients undergoing percutaneous coronary intervention (PCI). The findings indicate that pre-PCI CTI levels are significantly associated with adverse outcomes, suggesting its potential as an independent predictor of MACEs.

Background

Coronary artery disease (CAD) remains a leading cause of mortality and disability globally, with a notable incidence of MACEs post-PCI. Understanding the risk factors that contribute to these adverse outcomes is crucial for improving patient management and outcomes. The CTI, which combines inflammation and insulin resistance markers, may provide valuable insights into the cardiovascular risk profile of patients undergoing PCI.

Data Highlights

Key Findings

• CTI is an independent predictor of MACEs in patients undergoing PCI.
• There is a significant difference in adverse outcomes across different CTI levels.
• RCS analysis indicates a non-linear relationship between CTI and primary endpoints.
• CTI demonstrated good predictive ability for adverse outcomes, validated by subgroup and sensitivity analyses.
• Insulin resistance and inflammation are critical factors in the pathogenesis of cardiovascular diseases.

Clinical Implications

Clinicians should consider incorporating CTI levels into the risk assessment of patients undergoing PCI to better identify those at high risk for adverse cardiovascular events. This approach may enhance postoperative management strategies and improve patient outcomes.

Conclusion

The study underscores the importance of pre-PCI CTI levels as a significant predictor of MACEs, highlighting the need for further research to validate its clinical utility in risk stratification.

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