Current status and influencing factors of laryngopharyngeal reflux disease in outpatients with laryngeal diseases: key considerations for clinical practice - Report - MDSpire
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Current status and influencing factors of laryngopharyngeal reflux disease in outpatients with laryngeal diseases: key considerations for clinical practice
Clinical Report: Overview and Determinants of Laryngopharyngeal Reflux Disease
Overview
Laryngopharyngeal reflux disease (LPRD) is prevalent among outpatients with laryngeal disorders, significantly impacting their quality of life. This study identifies key risk factors and presents a predictive model for early diagnosis, demonstrating good diagnostic performance.
Background
LPRD is a common comorbidity in patients with laryngeal diseases, characterized by the reflux of gastric contents into the laryngopharynx. The condition can lead to misdiagnosis and delayed treatment, exacerbating symptoms and complications. Understanding the risk factors and developing effective diagnostic tools is crucial for improving patient outcomes.
Data Highlights
Risk Factor
Odds Ratio (OR)
95% Confidence Interval (CI)
Age ≥65 years
2.376
1.985–2.836
BMI ≥ 25 kg/m2
-
-
Smoking history
-
-
Preference for strong tea
-
-
Abnormal LES function
2.376
1.985–2.836
History of laryngeal surgery
-
-
Hypertension
-
-
Key Findings
LPRD is highly prevalent in outpatients with laryngeal diseases.
Independent risk factors include age ≥65 years, BMI ≥ 25 kg/m2, smoking history, and abnormal LES function.
The prediction model developed has a sensitivity of 0.723 and specificity of 0.892.
The area under the curve (AUC) for the model is 0.891, indicating good diagnostic performance.
Misdiagnosis of LPRD can lead to severe complications such as vocal cord nodules.
Clinical Implications
Healthcare professionals should be aware of the high prevalence of LPRD in patients with laryngeal disorders and consider the identified risk factors when assessing patients. The developed prediction model can aid in the early identification of high-risk patients, facilitating timely intervention.
Conclusion
LPRD poses significant challenges in the management of laryngeal diseases, but understanding its risk factors and utilizing a predictive model can enhance early diagnosis and improve patient care.
