Seasonal variation in Ménière disease: a systematic review and meta-analysis - Report - MDSpire

Seasonal variation in Ménière disease: a systematic review and meta-analysis

  • By

  • Xuanyu Shi

  • Linlin Wang

  • Xingqian Shen

  • Ziying Xu

  • Yangming Leng

  • Bo Liu

  • July 2, 2026

  • 0 min

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Clinical Report: Seasonal Patterns and Their Impact on Ménière Disease

Overview

This meta-analysis investigates the association between seasonal patterns and the occurrence of Ménière disease (MD). The findings indicate a slight increase in MD occurrences during spring and a decrease during winter.

Background

Ménière disease is a chronic inner ear disorder that significantly impacts patients' quality of life and poses economic challenges. Understanding the seasonal variations in MD occurrences may help identify triggers. Despite some studies suggesting seasonal patterns, the evidence remains inconsistent.

Data Highlights

SeasonOdds Ratio (OR)95% Confidence Interval (CI)
Spring1.031.02–1.04
Summer (reference)--
Autumn1.040.85–1.26
Winter0.920.91–0.93

Key Findings

  • The meta-analysis included five observational studies with a total of 1,001,636 participants.
  • Spring showed a higher occurrence of MD with an OR of 1.03 compared to summer.
  • Winter had a lower occurrence of MD with an OR of 0.92 compared to summer.
  • Autumn showed an OR of 1.04, indicating a slight increase in MD occurrences.
  • Subgroup and sensitivity analyses confirmed the robustness of the findings.

Clinical Implications

The seasonal variation in MD occurrences may inform future studies.

Conclusion

The study indicates that seasonal fluctuations may affect the occurrence of Ménière disease.

Related Resources & Content

  1. Frontiers | Seasonal variation in Ménière disease: a systematic review and meta-analysis
  2. Clinical Practice Guideline: Ménière’s Disease - American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS)
  3. What are the benefits and risks of different medications for Ménière's disease? | Cochrane
  4. Drugs - Real World Outcomes — Variation in Adverse Event Reporting by Season and Location
  5. Clinical Rheumatology — Impact of Seasonal Changes on the Severity of Widespread Pain in Female Fibromyalgia Patients: Insights from a Comprehensive National Registry
  6. Frontiers in Neurology — Endolymphatic hydrops in patients with migraine: a correlative study
  7. Frontiers in Immunology — Burden of novel and ultra-rare missense variants in the NF-κB pathway genes associated to Ménière’s disease
  8. Clinical Practice Guideline: Ménière’s Disease - American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS)
  9. What are the benefits and risks of different medications for Ménière's disease? | Cochrane
  10. Frontiers | Seasonal variation in Ménière disease: a systematic review and meta-analysis

Original Source(s)

Seasonal variation in Ménière disease: a systematic review and meta-analysis

  • by Xuanyu Shi, Linlin Wang, Xingqian Shen, Ziying Xu, Yangming Leng, Bo Liu

  • July 2, 2026

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