A multi-method study on GPs’ perspectives on Lipoprotein(a) as an actionable cardiovascular risk factor - Report - MDSpire

A multi-method study on GPs’ perspectives on Lipoprotein(a) as an actionable cardiovascular risk factor

  • By

  • Wann Jia Loh

  • Linh Thai

  • Yufan Yang

  • Jonathan Yeo

  • Bik Ling Poon

  • Andy Wong

  • Roy K. L. Teow

  • Elaine Lum

  • June 12, 2026

  • 0 min

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Clinical Report: Exploring General Practitioners' Views on Lipoprotein(a)

Overview

This study investigates general practitioners' perspectives on the detection and management of elevated Lipoprotein(a) [Lp(a)], highlighting significant barriers to routine testing and the positive impact of targeted educational interventions. The findings underscore the need for improved training and national management pathways to enhance Lp(a) awareness and treatment.

Background

Elevated Lp(a) is recognized as an independent risk factor for cardiovascular disease, yet it remains underdiagnosed and poorly managed globally. Despite recommendations for universal testing, only a small fraction of high-risk individuals are assessed for elevated Lp(a). Understanding general practitioners' views is crucial, as they play a key role in primary care and cardiovascular risk management.

Data Highlights

In a study involving 50 general practitioners, the LILAC-for-Lp(a) educational framework significantly improved GPs' confidence in managing Lp(a) (p < 0.001).

Key Findings

  • Only 2 out of 18 GPs routinely test for Lp(a) in high cardiovascular risk patients.
  • Barriers to Lp(a) testing include lack of management pathways, out-of-pocket costs, and low public awareness.
  • Pre- and post-education questionnaires indicated a positive shift in GPs' perspectives on Lp(a) testing after the LILAC training.
  • 80% of Singapore’s primary healthcare is provided by private-sector GPs, emphasizing their role in managing Lp(a).
  • Current guidelines recommend testing Lp(a) at least once in a lifetime for all adults.

Clinical Implications

Healthcare providers should prioritize training on Lp(a) to enhance detection and management in primary care settings. Establishing clear management pathways and subsidizing costs may facilitate broader implementation of Lp(a) testing.

Conclusion

The study highlights critical gaps in the management of elevated Lp(a) among general practitioners, while also demonstrating the effectiveness of educational interventions in improving awareness and confidence in handling this risk factor.

Related Resources & Content

  1. European Journal of Preventive Cardiology, 2023 -- The Risk of Atherosclerotic Cardiovascular Disease Linked to Lipoprotein(a) Remains Unaffected by C-Reactive Protein Levels
  2. European Journal of Preventive Cardiology, 2023 -- Lipoprotein (a) and incident coronary heart disease in the community: impact of traditional cardiovascular risk factors
  3. European Journal of Preventive Cardiology, 2023 -- Lipoprotein(a) and Its Association with Cardiovascular Risk: Recent Developments
  4. 2026 Guideline on the Management of Dyslipidemia - Professional Heart Daily | American Heart Association
  5. European Journal of Preventive Cardiology — Association of Conventional Risk Factors, Ideal Cardiovascular Health, and Increased Lipoprotein(a) Levels
  6. Lipoprotein(a) lowering by alirocumab reduces the total burden of cardiovascular events independent of low-density lipoprotein cholesterol lowering: ODYSSEY OUTCOMES trial
  7. Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease
  8. 2026 Guideline on the Management of Dyslipidemia - Professional Heart Daily | American Heart Association

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