Migraine with comorbid fibromyalgia: psychological burden and impact on frequency and severity of migraine attacks - Report - MDSpire

Migraine with comorbid fibromyalgia: psychological burden and impact on frequency and severity of migraine attacks

  • By

  • Amr Hassan

  • Mona Hussein

  • Rehab Magdy

  • Anas Elgenidi

  • Nahla Merghany

  • Ahmed Yehia Ismaeel

  • Mohamed Abdelghaffar

  • Osama Yacoub

  • May M. Fayez

  • Nourhan Abdelmohsen Taha

  • Ramez Reda Moustafa

  • Ahmed Essmat

  • April 30, 2026

  • 0 min

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Clinical Report: The Psychological Impact of Fibromyalgia on Migraine Patients

Overview

This study investigates the impact of fibromyalgia on migraine frequency and severity, revealing that patients with both conditions experience significantly higher migraine days and psychological distress compared to those with migraine alone. The findings underscore the need for integrated management strategies for these comorbid conditions.

Background

Migraine affects a substantial portion of the population, with a notable prevalence in Egypt. Fibromyalgia, characterized by widespread pain and psychological symptoms, often coexists with migraine, potentially exacerbating the frequency and severity of migraine attacks. Understanding this relationship is crucial for improving patient outcomes and tailoring treatment approaches.

Data Highlights

MeasureComorbid Migraine & FibromyalgiaMigraine Onlyp-value
Monthly Migraine Days (MMD)HigherLower< 0.001
HIT-6 ScoreHigherLower0.009
DASS-12 Total ScoreHigherLower< 0.001

Key Findings

  • Patients with comorbid migraine and fibromyalgia reported significantly higher monthly migraine days (MMD).
  • Higher headache impact test-6 (HIT-6) scores were observed in patients with both conditions.
  • Psychological distress, as measured by DASS-12, was significantly greater in patients with comorbid conditions.
  • Positive correlations exist between the FIQR total score and both MMD and HIT-6 scores.
  • There is a significant correlation between DASS-12 scores and both MMD and HIT-6 scores.

Clinical Implications

Healthcare providers should be aware of the increased frequency and severity of migraine attacks in patients with fibromyalgia. A multidisciplinary approach that addresses both the physical and psychological aspects of these comorbid conditions is essential for effective management.

Conclusion

The findings highlight the detrimental impact of fibromyalgia on migraine characteristics and the psychological burden faced by patients. Enhanced awareness and tailored treatment strategies are necessary to improve patient care.

References

  1. Clinical Rheumatology, 2025 -- Impact of Seasonal Changes on the Severity of Widespread Pain in Female Fibromyalgia Patients: Insights from a Comprehensive National Registry
  2. Pain Medicine, 2025 -- Proinflammatory diet is associated with higher pain, disease severity and biochemical parameters associated with inflammation in fibromyalgia
  3. Clinical Rheumatology, 2026 -- Perception and lived experience of movement in patients with fibromyalgia: a qualitative systematic review with meta-synthesis and meta-summary
  4. International Headache Society, 2024 -- International Headache Society global practice recommendations for the acute pharmacological treatment of migraine
  5. Clinical Rheumatology — The Paradox of Emotional Suppression: How Beliefs About Acceptable Emotions Influence Outcomes in Fibromyalgia
  6. Management of Fibromyalgia: An Update
  7. Association between headache frequency and risk for fibromyalgia in patients with migraine
  8. International Headache Society global practice recommendations for the acute pharmacological treatment of migraine - Francesca Puledda, Simona Sacco, Hans-Christoph Diener, Messoud Ashina, Haidar M. Al-Khazali, Sait Ashina, Rami Burstein, Eric Liebler, Andrea Cipriani, Min Kyung Chu, Alexandra Cocores, Freda Dodd-Glover, Esme Ekizoğlu, David Garcia-Azorin, Carl Göbel, Maria Teresa Goicochea, Amr Hassan, Koichi Hirata, Jan Hoffmann, Bronwyn Jenkins, Katharina Kamm, Mi Ji Lee, Yu-Hsiang Ling, Marco Lisicki, Daniele Martinelli, Teshamae S. Monteith, Raffaele Ornello, Aynur Ozge, Mario Peres, Patricia Pozo-Rosich, Volodymyr Romanenko, Todd J. Schwedt, Marcio Nattan P. Souza, Tsubasa Takizawa, Gisela M. Terwindt, Janu Thuraiaiyah, Mansoureh Togha, Nicolas Vandenbussche, Shuu-Jiun Wang, Shengyuan Yu, Cristina Tassorelli, 2024

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