Integrated heart rate and oxygen uptake recovery phenotypes reveal heterogeneous recovery patterns in coronary artery disease - Report - MDSpire

Integrated heart rate and oxygen uptake recovery phenotypes reveal heterogeneous recovery patterns in coronary artery disease

  • By

  • Benil Nesli Ata

  • Baris Unal

  • Merve Celik

  • Bugra Ince

  • Ece Cinar

  • July 9, 2026

  • 0 min

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Clinical Report: Combined Analysis of Heart Rate and Oxygen Uptake Recovery Profiles

Overview

This study investigates the relationship between heart rate recovery (HRR) and oxygen uptake (VO₂) recovery in patients with coronary artery disease (CAD). It identifies distinct recovery phenotypes.

Background

Heart rate recovery and oxygen uptake recovery are critical indicators of autonomic and metabolic recovery following exercise in patients with coronary artery disease. Current assessments often rely on peak exercise performance.

Data Highlights

ParameterCorrelation Coefficient (r)p-value
HRR1 and ΔVO₂10.519<0.001
HRR1 and ΔVO₂20.510<0.001
HRR1 and VO₂ recovery at 1 min0.496<0.001
HRR1 and VO₂ recovery at 2 min0.531<0.001

Key Findings

  • HRR1 is significantly correlated with ΔVO₂1 and ΔVO₂2.
  • Distinct recovery phenotypes were identified.
  • Patients with the Good HRR–Poor VO₂ phenotype exhibited significantly lower VO₂ recovery compared to the Poor HRR–Good VO₂ phenotype.
  • Recovery-phase variables may provide prognostic information independent of peak exercise performance.

Clinical Implications

The findings indicate the importance of considering both HRR and VO₂ recovery when evaluating post-exercise recovery in CAD patients.

Conclusion

The study highlights the multidimensional nature of post-exercise recovery in CAD.

Related Resources & Content

  1. JMIR Medical Informatics, 2026 -- AI-Powered Resting 12-Lead Electrocardiogram Algorithm for Predicting Low Peak Oxygen Consumption: Development and Validation Study
  2. European Journal of Preventive Cardiology, 2023 -- Comparison of exercise training modalities and change in peak oxygen consumption in heart failure with preserved ejection fraction: a secondary analysis of the OptimEx-Clin trial
  3. Intensive Care Medicine, 2026 -- Reproducible clinical archetypes in acute respiratory failure: a multi-cohort trajectory analysis
  4. European Journal of Preventive Cardiology, 2023 -- Combining Epicardial Adipose Tissue and Heart Rate Recovery in Adults with Cardiometabolic Risk Factors
  5. The prognostic value of heart rate recovery in patients with coronary artery disease: A systematic review and meta-analysis - ScienceDirect
  6. Cardiopulmonary exercise testing in clinical practice: Principles, applications, and basic interpretation - ScienceDirect
  7. 2024 ESC Chronic Coronary Syndromes guideline
  8. The prognostic value of heart rate recovery in patients with coronary artery disease: A systematic review and meta-analysis - ScienceDirect
  9. Cardiopulmonary exercise testing in clinical practice: Principles, applications, and basic interpretation - ScienceDirect

Original Source(s)

Integrated heart rate and oxygen uptake recovery phenotypes reveal heterogeneous recovery patterns in coronary artery disease

  • by Benil Nesli Ata, Baris Unal, Merve Celik, Bugra Ince, Ece Cinar

  • July 9, 2026

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