Efficacy and Safety of 3% Diquafosol Sodium with 0.1% Fluorometholone

Overview

This pilot study evaluates the efficacy and safety of a combination of 3% diquafosol sodium and 0.1% fluorometholone for managing postoperative dry eye in pterygium patients with preoperative tear deficiency. Results indicate improvements in tear film stability and symptoms compared to the control group.

Background

Postoperative dry eye is a common complication following pterygium surgery, particularly in patients with preoperative tear deficiency. The condition can lead to discomfort and ocular surface damage.

Data Highlights

Key Findings

• The observation group showed significantly longer tear break-up time (BUT) at 4 weeks postoperatively.
• Corneal fluorescein staining (CFS) scores were lower in the observation group compared to the control group.
• The Ocular Surface Disease Index (OSDI) scores were significantly lower in the observation group.
• Schirmer I test (SIt) values were higher in the observation group, indicating improved tear production.
• No significant differences in intraocular pressure (IOP) were observed between groups.
• Transient ocular stinging occurred in 4.88% of patients in the observation group, with no severe complications reported.

Clinical Implications

The study reports that the combination of diquafosol sodium and fluorometholone may improve outcomes in managing postoperative dry eye in pterygium patients with preoperative tear deficiency.

Conclusion

This pilot study indicates that the combination therapy may improve tear film stability and alleviate dry eye symptoms without significantly affecting intraocular pressure.

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