Universal opt-in HIV, HBV and HCV testing in an emergency department: implementation and outcomes of a comprehensive screening program - Report - MDSpire

Universal opt-in HIV, HBV and HCV testing in an emergency department: implementation and outcomes of a comprehensive screening program

  • By

  • Kira Sophia Hülsdünker

  • David Grieser

  • Pascal Migaud

  • Daniela Drauz

  • Keikawus Arastéh

  • Hartmut Stocker

  • December 15, 2025

  • 0 min

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Clinical Report: Outcomes of Universal HIV, HBV, HCV Screening in an ED Setting

Overview

A universal opt-in screening program for HIV, HBV, and HCV was implemented in a Berlin emergency department over 29 months, targeting patients aged 18–68 requiring blood tests. The initiative demonstrated feasibility in a high-prevalence urban setting, with structured patient education and consent processes supporting effective testing uptake.

Background

Blood-borne viruses such as HIV, HBV, and HCV remain significant global public health challenges, with millions affected worldwide. Early diagnosis is critical to improving outcomes and reducing transmission, yet late diagnosis persists as a barrier. Routine screening in healthcare settings, particularly emergency departments serving urban populations, can identify infections earlier than risk-based testing. Berlin, with a higher HIV prevalence than the national average, provides a relevant setting to evaluate universal BBV screening strategies.

Data Highlights

ParameterValue
Study periodJune 2021 – April 2024 (29 months analyzed)
HospitalSt. Joseph Hospital, Berlin
ED annual visits~50,000
Screening eligibilityAge 18–68, blood sample required
Berlin HIV prevalence0.4% (417 per 100,000)
Estimated unknown HIV cases in Berlin (2023)~1040
New HIV diagnoses in Berlin (2023)300
Late diagnosis proportion (Berlin)~33%

Key Findings

  • Universal opt-in BBV screening was feasible in a busy urban emergency department setting.
  • Patient education was delivered via multilingual materials and trained nursing staff, enhancing informed consent.
  • Screening targeted patients aged 18–68 undergoing blood draws, excluding occupational injury cases and those unable/unwilling to consent.
  • Berlin’s higher HIV prevalence supports the rationale for universal ED screening to identify undiagnosed infections.
  • Approximately one-third of new HIV diagnoses in Berlin were late-stage, underscoring the need for earlier detection strategies.

Clinical Implications

Implementing universal BBV screening in emergency departments can improve early detection of HIV, HBV, and HCV, especially in urban areas with elevated prevalence. Structured patient education and multilingual consent processes are critical to optimize participation. Such programs may reduce late diagnoses and subsequent transmission, aligning with public health targets.

Conclusion

This study supports the feasibility and potential impact of universal BBV screening in emergency departments within high-prevalence urban settings. Early identification through such initiatives can contribute to improved individual and public health outcomes.

References

  1. Robert Koch Institut 2023 -- HIV Epidemiology in Germany
  2. UNAIDS 2024 -- 95-95-95 Targets for HIV
  3. WHO 2022 -- Global Health Sector Strategy on Viral Hepatitis
  4. CDC 2006 -- Routine HIV Screening Recommendations
  5. Berlin Health Authority 2023 -- HIV Prevalence Data

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