Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation—a systematic review and meta-analysis - Report - MDSpire

Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation—a systematic review and meta-analysis

  • By

  • Yarui Huang

  • Qingrong Li

  • Xin Xu

  • Ju Li

  • Yan Zhu

  • Chengxin Luo

  • Jiegang Xu

  • Jiaming Liu

  • Jianmin Zhang

  • Ping Wang

  • Ya Tan

  • Yaqun Ding

  • Shuangnian Xu

  • Run Chen

  • Ling Wei

  • July 14, 2026

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Clinical Report: Impact of Donor KIR Genotypes on Survival Outcomes Following Allogeneic Hematopoietic Stem Cell Transplantation

Overview

This systematic review and meta-analysis evaluates the prognostic impact of donor KIR haplotypes on survival outcomes in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Background

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a critical treatment for various hematological malignancies, yet patient survival rates remain suboptimal due to complications such as relapse and graft-versus-host disease (GVHD). Recent research highlights the importance of non-HLA factors, including donor KIR genotypes, in influencing transplant outcomes.

Data Highlights

OutcomeHazard Ratio (HR)95% Confidence Interval (CI)P-value
Overall Survival0.680.56-0.82<0.0001
Relapse Incidence0.610.44-0.850.003
Relapse-Free Survival0.610.46-0.810.0008

Key Findings

  • Donor KIR B/X genotype is associated with significantly superior overall survival.
  • Reduced relapse incidence is observed in patients with donor KIR B/X genotype.
  • Improved relapse-free survival is linked to donor KIR B/X haplotype.
  • The study included 17 eligible studies in the meta-analysis.
  • Findings support the potential utility of KIR haplotypes as a biomarker for donor selection.

Clinical Implications

The association of donor KIR B/X haplotypes with improved survival outcomes suggests that KIR genotyping may be a consideration in donor selection for allo-HSCT.

Conclusion

The study provides evidence that donor KIR B/X genotypes are linked to favorable survival outcomes in allo-HSCT.

Related Resources & Content

  1. Bone Marrow Transplantation, 2023 -- Influence of Donor Age and Relationship on the Outcomes of Peripheral Blood Haploidentical Hematopoietic Cell Transplantation
  2. Bone Marrow Transplantation, 2022 -- Genetic Factors from Donors Affecting Thymopoiesis rs2204985 Influence Clinical Outcomes Following Single HLA Mismatched Hematopoietic Stem Cell Transplantation
  3. Blood Cancer Journal -- Effects of KIR ligand incompatibility on clinical outcomes of umbilical cord blood transplantation without ATG for acute leukemia in complete remission
  4. Allogeneic Hematopoietic Cell Donor Selection: Contemporary Guidelines from the NMDP/CIBMTR - PMC
  5. Donor Selection for Adults and Pediatrics - The EBMT Handbook - NCBI Bookshelf
  6. Bone Marrow Transplantation — Restoration of Natural Killer Cell Receptor Diversity Following Transplantation: Is Timing the Key Factor?
  7. Allogeneic Hematopoietic Cell Donor Selection: Contemporary Guidelines from the NMDP/CIBMTR - PMC
  8. Donor Selection for Adults and Pediatrics - The EBMT Handbook - NCBI Bookshelf
  9. Donor KIR genotype based outcome prediction after allogeneic stem cell transplantation: no land in sight
  10. Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML - PMC

Original Source(s)

Effects of donor killer-cell immunoglobulin-like receptor genotypes on clinical outcome after allogeneic hematopoietic stem cell transplantation—a systematic review and meta-analysis

  • by Yarui Huang, Qingrong Li, Xin Xu, Ju Li, Yan Zhu, Chengxin Luo, Jiegang Xu, Jiaming Liu, Jianmin Zhang, Ping Wang, Ya Tan, Yaqun Ding, Shuangnian Xu, Run Chen, Ling Wei

  • July 14, 2026

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