Clinical Report: Refractory Dyspepsia and Diffuse Gastric Atrophy in a Patient with Collagenous Gastritis
Overview
This case study presents a 35-year-old woman with refractory dyspepsia and a prior diagnosis of seronegative autoimmune gastritis (AIG). Comprehensive reassessment revealed collagenous gastritis (CG) as the underlying condition.
Background
Collagenous gastritis (CG) is a rare fibroinflammatory disorder characterized by thickened subepithelial collagen deposition and mucosal inflammation. Accurate diagnosis is critical, as CG can mimic more common forms of atrophic gastritis, such as autoimmune gastritis (AIG).
Data Highlights
Case report of a 35-year-old woman with a 7-year history of refractory dyspepsia, previously diagnosed with seronegative AIG. Key findings included:
Severe vitamin B12 deficiency (148 pg/mL)
Hypoferritinemia (12.86 μg/L)
Low serum gastrin (10.7 pg/mL)
Histopathological confirmation of CG with thickened collagen bands
Key Findings
The patient had a 7-year history of refractory dyspepsia.
Initial diagnosis of seronegative AIG was based on gastric atrophy and micronutrient deficiencies.
Comprehensive reassessment revealed atypical endoscopic findings inconsistent with AIG.
Histopathology confirmed collagenous gastritis with thickened subepithelial collagen bands.
Proton pump inhibitor therapy was initiated.
Clinical Implications
Clinicians should utilize comprehensive evaluations, including endoscopic and histological assessments, to avoid misdiagnosis.
Conclusion
Collagenous gastritis should be considered in the differential diagnosis of refractory dyspepsia.
