Association of antiretroviral therapy regimens with serum cortisol abnormalities in people living with HIV/AIDS: a retrospective study - Report - MDSpire

Association of antiretroviral therapy regimens with serum cortisol abnormalities in people living with HIV/AIDS: a retrospective study

  • By

  • Han Yajuan

  • Chen Xingxing

  • Jiang Huirong

  • Wan Jinshu

  • Zhang Yinhua

  • Pan Xiuzhen

  • Muhammad Tahir Khan

  • Xu Chao

  • Lin Sizhe

  • Pan Chih-Lin

  • Liu Yanrong

  • He Piao

  • June 26, 2026

  • 0 min

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Clinical Report: Impact of Antiretroviral Therapy Types on Serum Cortisol Levels

Overview

This study investigates the correlation between antiretroviral therapy (ART) regimens and serum cortisol levels in individuals with HIV/AIDS. A significant proportion of participants exhibited abnormal cortisol levels.

Background

The life expectancy of people living with HIV (PLWH) has improved due to effective antiretroviral therapy (ART). Understanding the effects of different ART regimens on hormonal levels, such as cortisol, is crucial.

Data Highlights

GroupFindings
Group AHigher diastolic blood pressure, longer duration of HIV diagnosis
Group BNormal cortisol levels
Group CElevated triglyceride levels compared to Group B

Key Findings

  • 47.9% of participants exhibited abnormal high cortisol levels.
  • Group A had significantly higher diastolic blood pressure and longer HIV diagnosis duration compared to Group C.
  • Mean triglyceride levels were significantly elevated in Group C compared to Group B.
  • The NRTIs + PIs regimen was associated with a higher likelihood of reduced cortisol levels compared to NRTIs + NNRTIs.
  • Longer duration of HIV diagnosis was independently associated with changes in cortisol levels.

Clinical Implications

Clinicians should monitor cortisol levels in PLWH, especially those on specific ART regimens.

Conclusion

The findings indicate that certain ART regimens may be associated with changes in cortisol levels among individuals with HIV/AIDS.

Related Resources & Content

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  4. Author(s)/Org, Source, Year -- Title
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  6. What's New: Adult and Adolescent ARV HIV Clinical Guidelines | NIH
  7. BHIVA guidelines on antiretroviral treatment for adults living with HIV-1
  8. Drug-Drug Interactions: Protease Inhibitors and Other Drugs
  9. Liverpool HIV Interactions
  10. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/208798Orig1s000Lbl.pdf
  11. Drug-Drug Interactions: Protease Inhibitors and Other Drugs | NIH
  12. Adrenal Insufficiency among People Living with HIV in Africa: Does Salivary Cortisol Make a Difference? - PubMed
  13. Frontiers | Association of Antiretroviral Therapy Regimens with Serum Cortisol Abnormalities in People Living with HIV/AIDS: A Retrospective Study

Original Source(s)

Association of antiretroviral therapy regimens with serum cortisol abnormalities in people living with HIV/AIDS: a retrospective study

  • by Han Yajuan, Chen Xingxing, Jiang Huirong, Wan Jinshu, Zhang Yinhua, Pan Xiuzhen, Muhammad Tahir Khan, Xu Chao, Lin Sizhe, Pan Chih-Lin, Liu Yanrong, He Piao

  • June 26, 2026

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