Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow-Up: Data From the Multicenter Osteoarthritis Study - Report - MDSpire
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Subtypes of Obesity and Changes in Functional Status Over Seven Years: Insights from the Multicenter Osteoarthritis Study

  • By

  • Kristine Godziuk

  • Sarah Tilley

  • Michael LaValley

  • Michael C. Nevitt

  • Cora E. Lewis

  • James C. Torner

  • Tuhina Neogi

  • May 12, 2026

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Subtypes of Obesity and Changes in Functional Status Over Seven Years

Overview

This study evaluates the impact of obesity subtypes on physical function in individuals with knee osteoarthritis over a seven-year period.

Background

Obesity is a significant risk factor for functional limitations in knee osteoarthritis (OA). Understanding the variations in physical function among individuals with obesity is crucial for developing targeted interventions.

Data Highlights

No numerical data available in the provided source.

Key Findings

  • Individuals with obesity and low muscle mass or cardiometabolic comorbidities had poorer physical function over seven years.
  • The overlap of low muscle mass and cardiometabolic comorbidities was associated with a greater negative impact on physical function.
  • Defining obesity solely by BMI may overlook important functional variations within this population.
  • Subtypes of obesity, such as sarcopenic obesity, may contribute differently to functional deterioration in knee OA.

Clinical Implications

Healthcare professionals should consider the presence of low muscle mass and cardiometabolic comorbidities when assessing functional status in patients with obesity and knee OA.

Conclusion

Further research is needed to evaluate targeted interventions for these populations.

Related Resources & Content

  1. Effects of Obesity on Initial Postoperative Outcomes After Total Knee Arthroplasty in Elderly Patients: A Comparative Analysis of Class I and Class II Obesity
  2. Obesity as a Non-Contraindication for Medial Oxford Unicompartmental Knee Arthroplasty: Analysis of Long-Term Patient Outcomes and Implant Longevity in 1000 Knees
  3. Correlation of In Vivo and Ex Vivo Photon-Counting CT Assessments of Subchondral Trabecular Bone Characteristics in Knee Osteoarthritis Patients
  4. The Role of Adipokines in Changes in Metabolic Health Over Time: Insights from the Atherosclerosis Risk in Communities (ARIC) Study
  5. Addressing sarcopenic obesity
  6. High prevalence and multifactorial risks of sarcopenia in knee osteoarthritis: a systematic review and meta-analysis
  7. Does metabolically healthy obesity increase the risk of knee and hand osteoarthritis? A population-based cohort study
  8. Comparative efficacy and safety of exercise modalities in knee osteoarthritis: systematic review and network meta-analysis
  9. Addressing sarcopenic obesity
  10. High prevalence and multifactorial risks of sarcopenia in knee osteoarthritis: a systematic review and meta-analysis - PubMed
  11. Does metabolically healthy obesity increase the risk of knee and hand osteoarthritis? A population-based cohort study - UK Biobank
  12. Comparative efficacy and safety of exercise modalities in knee osteoarthritis: systematic review and network meta-analysis | The BMJ
  13. Ultra-processed Foods and Muscle Fat Infiltration at Thigh MRI: Data from the Osteoarthritis Initiative | Radiology

Original Source(s)

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow-Up: Data From the Multicenter Osteoarthritis Study

  • by Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi

  • May 12, 2026

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