Significant Hemoptysis Following Left Atrial Appendage Occlusion in a Patient with Atrial Fibrillation and Thrombus: A Case Study - Report - MDSpire

Significant Hemoptysis Following Left Atrial Appendage Occlusion in a Patient with Atrial Fibrillation and Thrombus: A Case Study

  • By

  • Qiqi Jin

  • Jianjian Yang

  • Shufang Wu

  • Shanjiang Chen

  • January 5, 2026

  • 0 min

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Significant Hemoptysis Following Left Atrial Appendage Occlusion in a Patient with Atrial Fibrillation and Thrombus: A Case Study

Overview

This case study presents a rare occurrence of massive hemoptysis following left atrial appendage occlusion (LAAO) in an 86-year-old male with atrial fibrillation and thrombus. Despite successful LAAO, the patient experienced significant postoperative complications, highlighting the need for careful monitoring in similar cases.

Background

Atrial fibrillation (AF) is the most prevalent arrhythmia and is linked to a heightened risk of thromboembolic events, particularly strokes. The left atrial appendage (LAA) is the primary site for thrombus formation in non-valvular AF, making LAAO a critical intervention for thromboembolism prevention. Understanding the complications associated with LAAO is essential for improving patient outcomes.

Data Highlights

No numerical data or trial data was presented in the article.

Key Findings

  • The patient had a history of persistent non-valvular AF and left atrial appendage thrombus (LAAT).
  • Despite anticoagulation therapy, the LAAT persisted, leading to the decision for LAAO.
  • Massive hemoptysis occurred postoperatively, estimated at approximately 150 mL.
  • Coagulation studies indicated a prolonged aPTT due to intraoperative heparinization.
  • The patient's CHA2DS2-VASc score was 7, indicating a high risk for thromboembolism.

Clinical Implications

This case underscores the potential for serious complications, such as hemoptysis, following LAAO, even in patients with adequate anticoagulation. Clinicians should maintain a high index of suspicion for pulmonary complications and ensure close monitoring post-procedure.

Conclusion

The occurrence of massive hemoptysis following LAAO in this patient highlights the complexity of managing atrial fibrillation with thrombus. Ongoing assessment and tailored management strategies are crucial for optimizing patient safety.

References

  1. Clinical Research in Cardiology, 2023 -- Unintentional Decrease in Blood Pressure in Patients with a History of Hypertension as an Indicator of Central Pulmonary Artery Embolism
  2. Clinical Research in Cardiology, 2025 -- Evaluation of Treatment Approaches for Atrial Fibrillation Patients with Left Atrial Appendage Thrombus Despite Optimal NOAC Management
  3. Infection, 2025 -- Management of Hemoptysis in a Multidrug-Resistant Tuberculosis Patient: Effective Diagnosis via Photon Counting CT and Treatment of a Rasmussen Aneurysm
  4. SCAI, HRS Publish First Multi-Society Guidelines to Guide Transcatheter Left Atrial Appendage Occlusion (LAAO) for Stroke Prevention, 2025
  5. The ASCO Post — Risk of Atrial Fibrillation and Associated Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation
  6. Comparison of Anticoagulation With Left Atrial Appendage Closure After Atrial Fibrillation Ablation - American College of Cardiology
  7. Persistent Left Atrial Appendage Thrombus in Atrial Fibrillation Despite Anticoagulation - PubMed
  8. SCAI, HRS Publish First Multi-Society Guidelines to Guide Transcatheter Left Atrial Appendage Occlusion (LAAO) for Stroke Prevention | SCAI

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