Clinically probable alkaptonuria-associated ochronosis presenting as multilevel cervical disc herniation with myeloradiculopathy managed by three-level C4–7 anterior cervical discectomy and fusion: a case report - Report - MDSpire
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Clinically probable alkaptonuria-associated ochronosis presenting as multilevel cervical disc herniation with myeloradiculopathy managed by three-level C4–7 anterior cervical discectomy and fusion: a case report
Clinical Report: Multilevel Cervical Disc Herniation with Myeloradiculopathy
Overview
Revise to clarify that the diagnosis of alkaptonuria was clinically probable rather than confirmed.
Background
Alkaptonuria (AKU) is a rare metabolic disorder characterized by the accumulation of homogentisic acid, leading to ochronotic pigment deposition in connective tissues. Spinal involvement, particularly cervical disc herniation, is uncommon but can result in significant neurological compromise. Recognizing the signs of AKU during surgical procedures is crucial for appropriate diagnosis and management.
Data Highlights
No numerical or trial data was provided in the source material.
Key Findings
The patient exhibited progressive neck pain and bilateral upper-limb symptoms.
Cervical MRI revealed multilevel disc degeneration and significant stenosis at C4/5, C5/6, and C6/7.
Intraoperative findings included diffusely black-pigmented intervertebral discs, suggestive of ochronosis.
Postoperative recovery included early improvement in limb numbness and gait stability.
Standard cervical decompression and fusion principles were effective for neurologic compromise.
Clinical Implications
Surgeons should be aware of the potential for underlying metabolic disorders such as AKU when encountering black discs during cervical discectomy. Documentation and tissue sampling are essential for further evaluation and diagnosis.
Conclusion
Remove conclusions about the importance of recognizing findings unless explicitly stated.
