In-vitro flow assessment study of intra-saccular endovascular devices for brain aneurysm treatment: SEAL™ vs. WEB™ - Report - MDSpire

In-vitro flow assessment study of intra-saccular endovascular devices for brain aneurysm treatment: SEAL™ vs. WEB™

  • By

  • Hamid Mansouri

  • Nedim Gulkaya

  • Matthew J. Gounis

  • Mohammad AlMajali

  • Amit Chaudhari

  • Darwin G. Ramirez Abreu

  • Syed F. Zaidi

  • Yazan K. Ashouri

  • Naoki Kaneko

  • Brian T. Jankowitz

  • David J. Altschul

  • Boris Pabon

  • Pervinder Bhogal

  • Thomas J. Wolfe

  • Edgard L. Pereira

  • Aamir Badruddin

  • Laila Ibrahim

  • Omid Amili

  • Osama O. Zaidat

  • June 19, 2026

  • 0 min

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Clinical Report: In Vitro Evaluation of Flow Dynamics in Intra-Saccular Devices

Overview

This study evaluates the flow dynamics of SEAL™ and WEB™-SL devices in treating brain aneurysms using a novel in vitro method.

Background

Intrasaccular devices like SEAL™ and WEB™ are critical for treating wide-neck bifurcation aneurysms, which pose significant challenges in endovascular interventions. Understanding the flow dynamics of these devices is essential for optimizing their design and improving patient outcomes. The study employs particle image velocimetry (PIV) to assess device performance in a controlled setting.

Data Highlights

DeviceMean Residence Time (s)Vorticity Strength (1/s)Velocity Magnitude (mm/s)
Control0.042 ± 0.00666.48 ± 8.58109.4 ± 15.5
SEAL-BASE0.387 ± 0.12814.06 ± 2.8012.42 ± 3.8
SEAL-ARC0.33 ± 0.09213.94 ± 2.5314.2 ± 3.5
WEB-SL0.171 ± 0.03427.60 ± 4.1625.34 ± 3.16

Key Findings

  • Mean residence time was significantly higher for SEAL devices compared to control (p < 0.05).
  • Vorticity strength decreased significantly with SEAL devices compared to control (p = 0.007, 0.006).
  • Velocity magnitude showed greater reductions with SEAL-BASE and SEAL-ARC compared to WEB-SL (p = 0.006, 0.007).
  • No significant difference in performance was observed between the two SEAL configurations (p = 0.30, p = 0.29).
  • The PIV method effectively characterizes flow dynamics in neurointerventional devices.

Clinical Implications

Understanding these dynamics can aid in optimizing treatment strategies for wide-neck bifurcation aneurysms.

Conclusion

The study demonstrates that SEAL configurations achieve superior flow reduction compared to WEB-SL in a controlled aneurysm model.

Related Resources & Content

  1. Galaxy Therapeutics Submits Final Module of PMA to U.S. FDA for SEAL™ Device in Wide-Neck Bifurcation Aneurysms
  2. Determining Ideal Woven Endobridge (WEB) Device Size for Aneurysm Volume: Utilizing Automated Volumetric Analysis to Forecast Occlusion Outcomes Post-WEB Intervention
  3. WEB Embolization with Stent Support: Characteristics of Aneurysms, Clinical Outcomes, and a Case Study of Stent-Delivered WEB
  4. Retreatment of Previously Ruptured Aneurysms with Microsurgical Clipping Following Woven EndoBridge (WEB) Device Intervention: A Case Series from a Single Institution
  5. Evaluating the Woven EndoBridge Device: A Comparative Analysis of Pre-Clinical Animal Studies and Clinical Outcomes
  6. 2023 Guideline for the Management of Patients with Unruptured Intracranial Aneurysms
  7. European Stroke Organisation (ESO) guidelines on management of unruptured intracranial aneurysms
  8. Long-term outcomes of the Woven EndoBridge device for intracranial aneurysms: systematic review and meta-analysis
  9. Unruptured Intracranial Aneurysms | New England Journal of Medicine
  10. Safety and effectiveness of the Woven EndoBridge (WEB) system for the treatment of wide necked bifurcation aneurysms: final 5 year results of the pivotal WEB Intra-saccular Therapy study (WEB-IT) - PubMed
  11. 15 years of WEB embolization: a transformative journey in aneurysm treatment | Journal of NeuroInterventional Surgery
  12. Study Details | NCT05831202 | SEAL™IT: Saccular Endovascular Aneurysm Lattice System Interventional Pivotal Trial | ClinicalTrials.gov
  13. Galaxy Therapeutics Submits Final Module of PMA to U.S. FDA for SEAL™ Device in Wide-Neck Bifurcation Aneurysms
  14. Galaxy submits final PMA module for Seal device in wide-neck bifurcation aneurysms
  15. Treatment of a ruptured shallow trilobed cerebral aneurysm with the novel saccular endovascular aneurysm lattice (SEAL) device: A case report with one year follow-up - PMC
  16. Endovascular treatment of a symptomatic giant partially thrombosed aneurysm with saccular endovascular aneurysm lattice (SEAL) XL: The world's largest novel intrasaccular device - PubMed
  17. Literature review and DELPHI consensus on follow-up and retreatment of intracranial aneurysms with intrasaccular devices

Original Source(s)

In-vitro flow assessment study of intra-saccular endovascular devices for brain aneurysm treatment: SEAL™ vs. WEB™

  • by Hamid Mansouri, Nedim Gulkaya, Matthew J. Gounis, Mohammad AlMajali, Amit Chaudhari, Darwin G. Ramirez Abreu, Syed F. Zaidi, Yazan K. Ashouri, Naoki Kaneko, Brian T. Jankowitz, David J. Altschul, Boris Pabon, Pervinder Bhogal, Thomas J. Wolfe, Edgard L. Pereira, Aamir Badruddin, Laila Ibrahim, Omid Amili, Osama O. Zaidat

  • June 19, 2026

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