Impact of maternal physical activity on outcome of assisted reproduction - Report - MDSpire

Impact of maternal physical activity on outcome of assisted reproduction

  • By

  • James Geiger

  • Alexander Quaas

  • Philipp Quaas

  • Andreas Schötzau

  • Viola Heinzelmann-Schwarz

  • Ursula Gobrecht-Keller

  • Manuel Fischer

  • July 16, 2026

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Clinical Report: Effects of Maternal Exercise on Assisted Reproductive Technology Outcomes

Overview

This study evaluates the impact of self-reported physical activity on reproductive outcomes in patients undergoing assisted reproductive technology (ART). Moderate exercise (1-2 times per week) was associated with higher pregnancy and live birth rates compared to no exercise or high levels of activity.

Background

Understanding the influence of lifestyle factors, such as physical activity, on ART outcomes is crucial due to the rising prevalence of infertility and the increasing use of ART. Previous studies have produced conflicting results regarding the optimal level of exercise during ART cycles, highlighting the need for further investigation. This study aims to clarify the relationship between maternal exercise and reproductive success in ART.

Data Highlights

GroupPregnancy Rate per TransferLive Birth Rate per TransferCumulative Pregnancy Rate per OPUCumulative Live Birth Rate per OPU
Group A (No Exercise)32.5%23.0%52.5%37.2%
Group B (1-2 times/week)34.8%25.6%58.7%43.1%
Group C (≥3 times/week)29.7%22.4%49.5%37.1%

Key Findings

  • Patients exercising 1-2 times weekly had the highest pregnancy rate per embryo transfer (34.8%).
  • Live birth rate per transfer was also highest in Group B (25.6%) compared to Groups A and C.
  • Cumulative pregnancy rate per oocyte pick-up (OPU) was highest in Group B (58.7%).
  • Cumulative live birth rate per OPU was higher in Group B (43.1%) than in Groups A and C.
  • Moderate physical activity was associated with more favorable ART outcomes compared to both no exercise and high levels of physical activity.

Clinical Implications

The findings indicate a relationship between moderate physical activity and ART outcomes.

Conclusion

Moderate exercise is associated with reproductive outcomes in ART. Further research is warranted to explore the mechanisms underlying these associations.

Related Resources & Content

  1. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Elevated Estradiol Levels Following IVF Linked to Higher Risk of Glucose Metabolic Disorders in Offspring
  2. BMC Pregnancy and Childbirth, 2026 -- Effects of different types of exercise interventions on perinatal depression, anxiety, and quality of life: a systematic review and meta-analysis
  3. Frontiers in Endocrinology, 2026 -- Editorial: Advancing reproductive outcomes: integrating molecular, metabolic, and endocrine insights into oocyte maturation
  4. BMC Pregnancy and Childbirth, 2026 -- The effect of regular exercise on general and mental fatigue and motivation during pregnancy: a randomized controlled trial
  5. Pregnant & Postpartum Activity: An Overview | Physical Activity Basics | CDC, 2025
  6. Impact of physical activity on frozen embryo transfer outcomes - ScienceDirect, 2026
  7. Natural ovulation versus programmed regimens before frozen embryo transfer in ovulatory women: multicentre, randomised clinical trial, 2025
  8. Pregnant & Postpartum Activity: An Overview | Physical Activity Basics | CDC
  9. Impact of physical activity on frozen embryo transfer outcomes - ScienceDirect
  10. Natural ovulation versus programmed regimens before frozen embryo transfer in ovulatory women: multicentre, randomised clinical trial

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