Association between neurodegenerative plasma biomarkers and geriatric depression in older adults with and without clinical dementia in Kinshasa, Democratic Republic of the Congo - Report - MDSpire
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Association between neurodegenerative plasma biomarkers and geriatric depression in older adults with and without clinical dementia in Kinshasa, Democratic Republic of the Congo
Clinical Report: Linking Plasma Biomarkers of Neurodegeneration to Geriatric Depression
Overview
This study investigates the association between plasma biomarkers of neurodegeneration and geriatric depression in older adults in Kinshasa, Democratic Republic of the Congo. Findings indicate that GFAP and NfL are significantly associated with higher odds of geriatric depression, particularly in individuals with suspected Alzheimer's disease.
Background
Geriatric depression is prevalent among older adults, especially those with dementia, and can significantly impact morbidity. Understanding the relationship between neurodegenerative biomarkers and depression is crucial, particularly in sub-Saharan Africa where such studies are limited. This research aims to fill that gap by examining older adults with and without clinical dementia.
Data Highlights
Biomarker
Odds Ratio
p-value
GFAP
1.98 (1.17–3.67)
0.02
NfL
1.76 (1.06–3.20)
0.04
Key Findings
80% of participants suspected of having Alzheimer's disease exhibited geriatric depression.
Participants with dementia scored significantly lower on cognitive tests compared to those without dementia.
GFAP and NfL were significantly associated with higher odds of geriatric depression.
Other plasma biomarkers measured were not associated with depression.
High blood pressure was common in participants with suspected Alzheimer's disease (60%).
Clinical Implications
The findings suggest that monitoring GFAP and NfL levels may provide insights into the risk of geriatric depression in older adults, particularly those with dementia. This could inform clinical assessments and interventions in similar populations.
Conclusion
This study highlights the potential role of neurodegenerative biomarkers in understanding geriatric depression among older adults in sub-Saharan Africa, warranting further research in this area.
by Nathan Tsengele, Alfred Sodi Magudigana, Guy Gikelekele, Emmanuel Epenge, Guy Kangula, Eric Muteba Vukumuna, Abraham Mifundu Bilongo, Said Mbuku Nguala, Degani Banzulu Bomba, Gilbert Mananga Lelo, Adelin N’situ Mankubu, Jean Ikanga
