Guillain-Barré syndrome presenting with abdominal pain as the initial manifestation: a case report - Report - MDSpire

Guillain-Barré syndrome presenting with abdominal pain as the initial manifestation: a case report

  • By

  • Zi-Zhen Yin

  • Yu Liu

  • June 11, 2026

  • 0 min

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Clinical Report: Initial Presentation of Guillain-Barré Syndrome with Abdominal Pain

Overview

This case report highlights a rare presentation of Guillain-Barré syndrome (GBS) in a 62-year-old male, where abdominal pain was the initial symptom. The case underscores the diagnostic challenges faced by clinicians when GBS presents atypically, potentially leading to delays in treatment.

Background

Guillain-Barré syndrome is an acute immune-mediated polyneuropathy typically characterized by ascending limb weakness and sensory disturbances. However, its presentation with abdominal pain is uncommon and can complicate diagnosis, as abdominal pain may lead to misdiagnosis of other conditions. Recognizing atypical presentations of GBS is crucial for timely intervention and management.

Data Highlights

No numerical data or trial data presented in the article.

Key Findings

  • A 62-year-old male presented with acute abdominal pain, initially diagnosed as acute cholecystitis.
  • Progressive limb weakness and loss of tendon reflexes developed, leading to a diagnosis of GBS.
  • Abdominal pain as the initial symptom may delay the diagnosis of GBS.
  • Physicians should maintain a high suspicion for GBS in patients presenting with abdominal pain and neurological deterioration.
  • Timely recognition of GBS is essential to prevent complications such as respiratory distress.

Clinical Implications

Clinicians should be aware that GBS can present with atypical symptoms such as abdominal pain, which may lead to misdiagnosis. A high index of suspicion for GBS in patients with unexplained abdominal pain and rapid neurological decline is essential for timely diagnosis and management.

Conclusion

This case emphasizes the importance of recognizing atypical presentations of Guillain-Barré syndrome to avoid diagnostic delays. Early identification and intervention are critical in managing this potentially life-threatening condition.

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  4. Infection -- A Unique Clinical Presentation: Concurrent Infections Leading to Guillain-Barré Syndrome, Recurrent Fever, and Mesenteric Lymphadenopathy
  5. EAN Guidelines, 2025 -- EAN clinical infographic
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  7. PMC -- Rare Abdominal Pain Onset in Guillain-Barré Syndrome: A Case Report of Acute Motor Sensory Axonal Neuropathy
  8. Neurology -- Efficacy and Safety of Targeted Immunotherapy with ANX005 in Treating Guillain-Barré Syndrome: A Phase 3 Multicenter Study (PL5.006)
  9. https://www.ean.org/fileadmin/user_upload/ean/ean/research/EAN_Guidelines/Infographic_Guidelines_2025_Online_version.pdf
  10. Critical insights for intensivists on Guillain-Barré syndrome | Annals of Intensive Care | Springer Nature Link
  11. Rare Abdominal Pain Onset in Guillain-Barré Syndrome: A Case Report of Acute Motor Sensory Axonal Neuropathy - PMC
  12. Efficacy and Safety of Targeted Immunotherapy with ANX005 in Treating Guillain-Barré Syndrome: A Phase 3 Multicenter Study (PL5.006) | Neurology

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